Commercial Supply Sofosbuvir and Related Intermediates:
Sofosbuvir CAS: 1190307-88-0
N4-Benzoylcytosine CAS: 26661-13-2
triphenyl(1-[ethoxycarbonyl]ethylidene)phosphorane CAS: 21382-82-1
Pentafluorophenol CAS: 771-61-9
N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester CAS: 1334513-02-8
| Name | Sofosbuvir |
| CAS Number | 1190307-88-0 |
| CAT Number | RF-API06 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C22H29FN3O9P |
| Molecular Weight | 529.45 |
| Melting Point | 120.0~125.0℃ |
| Density | 1.41 |
| Solubility | Soluble in DMF, DMSO, Ethanol |
| Shipping Condition | Under Ambient Temperature |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystalline Powder |
| Identification | HPLC; RT |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| E.E | ≥99.0% |
| Loss on Drying | ≤1.0% |
| Residue on Ignition | ≤0.20% |
| Single Impurity | ≤0.50% |
| Total Impurities | ≤1.0% |
| Heavy Metals | ≤20ppm |
| Residual Solvents | Meet the requirements of specifications |
| Methanol | ≤1500ppm |
| TBME | ≤2500ppm |
| Dichloromethane | ≤720ppm |
| Tetrahydrofuran | ≤720ppm |
| Toluene | ≤60ppm |
| Test Standard | Enterprise Standard |
| Usage | Sofosbuvir (CAS: 1190307-88-0) in the treatment of Hepatitis C Virus (HCV) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Sofosbuvir (CAS: 1190307-88-0) (formally labeled as PSI-797, GS-7977) is a phosphoramidate prodrug and nucleotide polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection. It is recommended to be used in combination with other drugs (such as velpatasvir) for the first-line treatment for HCV genotypes 1, 2, 3, 4, 5, and 6. It takes effect through acting as a nucleotide analog inhibitor, being capable of specially inhibiting the HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase.