Manufacturer Supply, High Quality, Commercial Production
Chemical Name: (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-thienyl)propanamine
CAS: 132335-44-5
| Chemical Name |
(S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)propanamine |
| Synonyms |
(S)-3-(Dimethylamino)-1-(2-Thienyl)-1-Propanol; (S)-2-[3-(Dimethylamino)-1-Hydroxypropyl]thiophene; Duloxetine Intermediate AA |
| CAS Number |
132335-44-5 |
| CAT Number |
RF-PI1046 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C9H15NOS |
| Molecular Weight |
185.29 |
| Melting Point |
77.0~80.0℃ |
| Specific Rotation [a]20/D |
-4.0° to -8.0° (C=1, Methanol) |
| Solubility |
Soluble in Methanol |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White Powder |
| Purity / Analysis Method |
>99.0% (GC) |
| Moisture (K.F) |
<0.50% |
| (S)-3-(Dimethylamino)-1-(Thiophen-3-yl)propan-1-ol |
<0.05% |
| Single Impurity |
≤ 0.20% |
| R-Isomer |
<0.50% |
| Total Impurities |
<0.50% |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Duloxetine Hydrochloride (CAS: 136434-34-9) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
(S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl)propanamine (CAS: 132335-44-5) is a key intermediate of Duloxetine Hydrochloride (CAS: 136434-34-9). Duloxetine Hydrochloride is used for the treatment of depression, was successfully developed by Eli Lilly Company. Duloxetine hydrochloride is a new kind of selective dual inhibitor of 5 hydroxy trptamine (5-HT) and norepinephrine reuptake, and thus having antidepressant effect, while also having inhibitory effect on the central pain. Its pharmacological characteristic is being able to inhibit neuronal pre-synaptic membrane’s reuptake on 5-hydroxy trptamine and norepinephrine but instead have a low inhibitory effect on the reuptake of dopamine. Duloxetine hydrochloride is indicated for depression and it is effective in treating both endogenous and non-endogenous depression as well as the feeling of pain associated with depression.