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Commercial Supply Palonosetron Hydrochloride and Related Intermediates:
1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 1914-65-4
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API
| Chemical Name |
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid |
| Synonyms |
(1S)-1,2,3,4-Tetrahydronaphthalene-1-Carboxylic acid |
| CAS Number |
85977-52-2 |
| CAT Number |
RF-CC111 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C11H12O2 |
| Molecular Weight |
176.21 |
| Density |
1.186g/cm3 |
| Melting Point |
54.0~56.0℃ |
| Boiling Point |
342.7°C at 760 mmHg |
| Refractive Index |
1.576 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White or Almost White Crystalline Powder |
| Chemical Purity |
≥99.0% |
| Enantimoer Excess |
e.e. ≥99.0% |
| Isomer Impurity |
≤1.0% |
| Loss on Drying |
≤0.50% |
| Relate Substance |
≤1.0% |
| Moisture (K.F) |
≤1.0% |
| Specific Rotation [α]D20 |
-59.0°~ -63.0°(C=0.3 in Benzence) |
| Heavy Metals |
≤20ppm |
| Storage |
5-8℃ Airtightness |
| Test Standard |
Enterprise Standard |
| Usage |
Palonosetron Hydrochloride (CAS: 135729-62-3) Intermediates |
(S)-1,2,3,4-tetrahydro-1-Naphthoic Acid CAS: 85977-52-2 Route of Synthesis
Package: Bottle, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) with high quality. It is an intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3).
Palonosetron Hydrochloride (CAS: 135729-62-3) is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (~40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. With 1,2,3,4-tetrahydro-1-Naphthoic Acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
