Progesterone CAS 57-83-0 Assay 97.0~103.0%

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Progesterone (CAS: 57-83-0) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Progesterone (CAS: 57-83-0), Please contact: alvin@ruifuchem.com

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Progesterone
C21H30O2 314.47
Pregn-4-ene-3,20-dione.
Progesterone [57-83-0].
Progesterone contains not less than 97.0 percent and not more than 103.0 percent of C21H30O2, calculated on the dried basis.
Packaging and storage- Preserve in tight, light-resistant containers. Store at 25, excursions permitted between 15 and 30.
USP Reference standards <11>-
USP Progesterone RS
Identification-
A: Infrared Absorption <197K>.
B: Ultraviolet Absorption <197U>-
Solution: 10 µg per mL.
Medium: methanol.
Melting range <741>: between 126 and 131. It may exist also in a polymorphic modification, melting at about 121.
Specific rotation <781S>: between +175 and +183.
Test solution: 20 mg per mL, in dioxane.
Loss on drying <731>- Dry it in vacuum over silica gel for 4 hours: it loses not more than 0.5% of its weight.
Assay-
Mobile phase- Prepare a filtered and degassed mixture of water and isopropyl alcohol (72:28). Make adjustments if necessary (see System Suitability under Chromatography 621).
Internal standard solution- Transfer about 66 mg of methyltestosterone to a 10-mL volumetric flask, add dilute alcohol (85 in 100) to volume, and mix.
Standard preparation- Dissolve an accurately weighed quantity of USP Progesterone RS in dilute alcohol (85 in 100) to obtain a solution having a known concentration of about 2.5 mg per mL. Transfer 4.0 mL of this solution to a 10-mL volumetric flask, add 1.0 mL of Internal standard solution, then add dilute alcohol (85 in 100) to volume, and mix to obtain a solution having a known concentration of about 1 mg of USP Progesterone RS per mL.
Assay preparation- Transfer about 10 mg of Progesterone, accurately weighed, to a 10-mL volumetric flask, add 1.0 mL of Internal standard solution, then add dilute alcohol (85 in 100) to volume, and mix.
Chromatographic system (see Chromatography <621>)- The liquid chromatograph is equipped with a 254-nm detector and a 4-mm × 30-cm column that contains 10-µm packing L1. The flow rate is about 1.5 mL per minute. Chromatograph the Standard preparation, and record the peak responses as directed for Procedure: the resolution, R, between the analyte and internal standard peaks is not less than 3.5; and the relative standard deviation for replicate injections is not more than 1.5%.
Procedure- Separately inject equal volumes (5 µL) of the Standard preparation and the Assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. The relative retention times are about 2.0 for progesterone and 1.0 for methyltestosterone. Calculate the quantity, in mg, of C21H30O2 in the portion of Progesterone taken by the formula:
10C(RU / RS)
in which C is the concentration, in mg per mL, of USP Progesterone RS in the Standard preparation; and RU and RS are the peak response ratios obtained from the Assay preparation and the Standard preparation, respectively.

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Risk Codes R40 - Limited evidence of a carcinogenic effect
R45 - May cause cancer
R62 - Possible risk of impaired fertility
R36 - Irritating to the eyes
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R11 - Highly Flammable
Safety Description S36/37 - Wear suitable protective clothing and gloves.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53 - Avoid exposure - obtain special instructions before use.
S16 - Keep away from sources of ignition.
UN IDs UN 1648 3 / PGII
WGK Germany 3
RTECS TW0175000
HS Code 2937239090

Progesterone (CAS: 57-83-0) is a synthetic progestational agent similar to the endogenous progesterone used in hormone therapy or as a female contraceptive. Mimicking the action of progesterone, hydroxyprogesterone caporate binds to and activates nuclear progesterone receptors in the reproductive system and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. Progesterone, along with pregnenolone, is the biosynthetic precursor of all other steroid hormones. Progesterone is used as a contraceptive, for amenorrhea, for premenopausal syndrome, infertility, incomplete pregnancies, and anovulatory uterine bleeding.
1. Biochemical research; Pregnancy hormone drugs, clinical treatment for inertial abortion, dyspenorrhea, amenorrhea and other diseases.
2. Hormone drugs. Mainly promote and maintain the changes of the uterus in the first trimester, used for habitual abortion, irregular menstruation, etc.
3. It belongs to steroid hormone and pregnancy hormone. It can treat threatened abortion.
4. Induce the maturation and secretory activity of the uterine wall; Inhibition of ovulation. Progestin and the occurrence of breast cancer have close relationship. 

1. Progesterone can maintain the female animal pregnancy, and cause a series of physiological changes, such as inhibition of female estrus.
2. Progesterone has the power to promote the thickening of the lining of the uterus, promote the bending of the gland and to increase secretion function.
3. Progesterone can inhibit the peristalsis of the uterus, and contribute to the cervix contraction, secretion of mucus, etc.. These physiological changes provide suitable environment for the operation, growth and development of early embryos, as well as the continued growth of the fetus.
4. Small amount of progesterone is also used in combination with the hormone estrogen to promote female estrus. The synergy between progesterone and prolactin can promote the development of mammary glands.
5. Progesterone is involved in the feedback regulation of the hypothalamus and anterior pituitary, which makes the balance of the animal reproductive hormones. In vivo, progesterone content of all sorts of livestock follicular phase is below 1 ng/ml, while in bovine corpus luteum period is approximately 4 ng/ml, pregnancy period is about 18 ng/ml.
6. Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.. In addition, progesterone also behaves as steroid hormone drug as well as progestogens, which is used in treatment of threatened abortion.