Manufacturer with High Purity and Stable Quality
Chemical Name: Citicoline Sodium
Synonyms: CDPC; CDP-Choline; Cytidine 5'-Diphosphocholine Sodium Salt
CAS: 33818-15-4
Appearance: White Crystalline or Crystalline Powder, Odorless
Purity: ≥98.0% (Calculated on the dried basis)
| Chemical Name |
Citicoline Sodium |
| Synonyms |
CDPC; CDP-Choline; Cytidine 5'-Diphosphocholine Sodium Salt |
| CAS Number |
33818-15-4 |
| CAT Number |
RF-API09 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C14H27N4NaO11P2 |
| Molecular Weight |
512.32 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White Crystalline or Crystalline Powder, Odorless |
| Solubility |
Freely Soluble in water, insoluble in ethanol, in acetone and in chloroform |
| Identification |
The color of the solution reaction was positive reaction |
| Identification |
The retention time of major peak of the sample solution should correspond to that of reference standard. |
| Identification |
The infrared absorption spectrum is concordant with the reference spectrum |
| Identification |
The aquous solution yields the reaction characteristic of sodium salts |
| Clarity and Colour of Solution |
Should be Clear and Colorless |
| Chlorides |
≤0.05% |
| Ammonium Salt |
≤0.05% |
| Iron |
≤0.01% |
| Phosphate |
≤0.10% |
| Loss on Drying |
≤6.0% |
| Heavy Metals |
≤0.0005% |
| Arsenic |
≤0.0001% |
| Bacterial endotoxins |
≤0.30 EU/mg |
| Total bacterial count |
≤1000cfu/g |
| Yeast & Molds |
≤100cfu/g |
| E.coli |
Not Detected |
| 5'-CMP |
≤0.30% |
| Other Simple impurity |
≤0.20% |
| Other Total Impurities |
≤0.70% |
| Residual Solvent Methanol |
≤0.30% |
| Residual Solvent Ethanol |
≤0.50% |
| Residual Solvent Acetone |
≤0.50% |
| Purity |
≥98.0% (Citicoline Sodium, Calculated on the dried basis) |
| Test Standard |
Chinese Pharmacopoeia (None-Sterile APIS) |
| Usage |
API; Pharmaceutical Intermediates |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.
Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory.