Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of L-Valinol (H-Val-ol) (CAS: 2026-48-4) with high quality. Ruifu Chemical supplys a series of amino acids. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase L-Valinol, Please contact: alvin@ruifuchem.com
| Chemical Name |
L-Valinol |
| Synonyms |
H-Val-ol; L-Val-ol; L-(+)-Valinol; (+)-Valinol; H-Valinol; (S)-2-Amino-3-Methyl-1-Butanol; (S)-2-Amino-3-Methylbutan-1-ol |
| Stock Status |
In Stock, Production Capacity to Tons per Month |
| CAS Number |
2026-48-4 |
| Molecular Formula |
C5H13NO |
| Molecular Weight |
103.17 g/mol |
| Melting Point |
30.0~34.0℃ |
| Boiling Point |
80.0~81.0℃/8 mm Hg(lit.) |
| Density |
0.926 g/mL at 25℃(lit.) |
| Refractive Index n20/D |
1.4538~1.4558(lit.) |
| Sensitive |
Air Sensitive |
| Water Solubility |
Soluble in Water |
| Storage Temp. |
Cool & Dry Place (2~8℃) |
| COA & MSDS |
Available |
| Category |
Amino Alcohols |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White Solid or Colorless Liquid |
Complies |
| Specific Rotation [α]20/D |
+16.0°±1.0° (C=10, C2H5OH) |
+16.5° |
| Melting Point |
30.0~34.0℃ |
30.0~33.0℃ |
| Water by Karl Fischer |
<0.50% |
0.15% |
| Heavy Metals (Pb) |
≤10ppm |
<10ppm |
| Single Impurity |
≤0.50% |
Complies |
| Total Impurities |
≤1.00% |
Complies |
| Purity / Analysis Method |
≥99.0% (GC) |
99.37% |
| E/E |
≥99.0% |
Complies |
| Infrared Spectrum |
Conforms to Structure |
Complies |
| Note |
This product is low melting point solid, may change state in different environments (solid, liquid or semi-solid) |
| Conclusion |
The product has been tested & complies with the specifications |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. It is sensitive to air. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes
R36 - Irritating to the eyes
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
WGK Germany 3
FLUKA BRAND F CODES 10-23
HS Code 2922491990
Hazard Class IRRITANT
L-Valinol Method of Analysis (GC)
1 Principle The sample is vaporized through the chromatographic column so that the components to be measured are separated, and the hydrogen flame ionization detector is used to detect the number. The main peak content is quantified according to the mechanism.
2. Instrument
Carrier gas: more than 99.95% nitrogen
Gas: greater than 99.95% hydrogen
Auxiliary gas: more than 99.95% air
Chromatograph: Lunan Chemical Instrument Factory 6800A gas chromatograph
Column: SE-54 capillary column (30M)
Detector: hydrogen flame ionization detector.
3. Application reagent: ethanol
4. Test conditions
Temperature of detector: 250℃
Vaporizing chamber temperature: 250℃
Column temperature: 160℃
Pre-column pressure: 0.05MPa
Hydrogen: 0.06MPa
Air: 0.06MPa
Sample size: 0.1ul
Shunt ratio: 50:1
Sample preparation: The sample is dissolved in ethanol
Method for chiral analysis of Valinol
Fmoc-Valinol was prepared by reaction of 1mg/ mg Valinol with Fmoc-OSU. 1mg valerine modified by Fmoc
Dissolved with 1ml of MEOH, 2ml of the sample was injected into a HPLC assay device connected to a chiral assay column
To the flow rate of 0.5ml/ s, the FMOC-L-VALINOL peak at 19 seconds, the FMOC-D-VALINOL peak at 58 seconds.
Method for the determination of Valinol rotation
1. After the powder is switched on, turn on the power switch and wait for 15min to make the sodium lamp glow stably.
2. Turn on the light source switch, and the sodium lamp is lit under DC power supply.
3. Prepare the test tube.
4, in the tube has been prepared to inject trichloromethane solvent, press the "zero" key, so that the display is zero.
5. Remove the blank solvent and inject the sample to be tested.
6, sample preparation: say 2.5g sample with water volume to 25ml.
7. Press "Measurement" to display the first measurement result, press "retest" to display the second result, and press "Retest" again.
The third result is displayed.
8. Calculation:
20 a *100
[a]=-------------------------
D m l*------------*100
25
In the formula, a is the average value of the three measurement results.
l: test tube with length of 1dm.
m: The quality of the sample.
L-Valinol (H-Val-ol) (CAS: 2026-48-4), can be used in peptide synthesis, can be also used as an organic synthesis intermediate, pharmaceutical intermediate, biochemical reagent or chemical reagent. L-(+)-Valinol reacts with aldehydes and nitriles to form imines and oxazolines, respectively, for asymmetric synthesis. It is also used for preparation of 4-isopropyloxazolidinones, employed in stereocontrolled aldol and alkylation reactions, synthesis of chiral 2-thiazolidinethiones for aldol reactions, asymmetric alkylation of condensation product with keto acids, asymmetric reactions of its amidines and imines and oxidation of N-protected derivative to the aldehyde.