Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of L-Hydroxyproline (H-Hyp-OH) (CAS: 51-35-4) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase L-Hydroxyproline, Please contact: alvin@ruifuchem.com
| Chemical Name | L-Hydroxyproline |
| Synonyms | H-Hyp-OH; trans-4-Hydroxy-L-Proline; H-L-Hyp-OH; H-trans-Hyp-OH; L-Hyp-OH; trans-L-4-Hydroxyproline; (2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid |
| Stock Status | In Stock, Production Capacity 35 Tons per Month |
| CAS Number | 51-35-4 |
| Molecular Formula | C5H9NO3 |
| Molecular Weight | 131.13 g/mol |
| Melting Point | 273℃(dec.)(lit.) |
| Sensitive | Air Sensitive |
| Solubility in Water | Almost Transparency |
| Storage Temp. | Cool & Dry Place (≤25℃) |
| COA & MSDS | Available |
| Category | Unusual Amino Acids |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Appearance | White Crystals or Crystalline Powder | Complies |
| Identification | The infrared Absorption Spectrum | Complies |
| State Of Solution | ≥95.0% | 98.5% |
| Specific Rotation [α]20/D | -74.0° to -77.0° (C=4 in H2O) | -75.2° |
| pH | 5.0~6.5 | 5.8 |
| Chloride (Cl) | ≤0.020% | <0.020% |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Iron (Fe) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤1ppm | <1ppm |
| Other Amino Acids | Conforms | Conforms |
| Loss on Drying | <0.20% | 0.11% |
| Residue on Ignition | <0.10% | 0.08% |
| H-Hyp-OH Assay | 98.5~101.0% | 99.4% |
| Conclusion | This Product by Inspection Accords with the AJI92 Standard | |
According to AJI92 standard:
Specific rotation: dried sample, C=4, H2O
Transmittance Test: 1.0g in 10mL of H2O, spectrophotometer, 430nm, 10nm cell thickness.
Chloride (Cl): 0.7g, A-1, ref: 0.40ml of 0.01N HCl
Ammonium (NH4): A-1
Sulfate (SO4): 1.2g, (1), ref: 0.50mL of 0.01N H2SO4
Iron (Fe): 1.5g, ref: 1.5mL of Iron Std, (0.01mg/mL)
Heavy metals (Pb): 2.0g, (1), ref: 2.0mL of Pb Std, (0.01mg/mL)
Arsenic (As2O3): 2.0g, (1), ref: 2.0mL of As2O3 Std.
Other amino acids: test sample: 10μg G-1-a
Loss on drying: at 105℃ for 3 hours
Residue on ignition:
Assay Test: dried sample, 130mg, 3mL of formic acid, 50mL of glacial acetic acid, 0.1N HClO4, 1mL=13.113mg L-Hydroxyproline.
PH: 1.0g in 10mL of H2O
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry (≤25℃) and ventilated warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
Safety Description
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S27 - Take off immediately all contaminated clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
RTECS TW3586500
TSCA Yes
HS Code 2922491990
Hazard Class IRRITANT
L-Hydroxyproline (H-Hyp-OH) (CAS: 51-35-4), A non-essential amino acid. Can be isolated from gelatin. An optically active form of 4-Hydroxyproline having L-trans-configuration. Unusual amino acids, used in peptide synthesis, pharmaceutical intermediates, biochemical reagents, chemical reagents. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is used as an intermediate for a range of pharmaceutical active ingredients. L-Hydroxyproline is a common non-standard protein amino acid, as the main raw material of antiviral drug Azanavir, it has high application value. L-Hydroxyproline is generally used as a food additive (used as a sweetener), and the use of a relatively large amount as an intermediate for the side chain of Peinan in medicine. Flavor enhancer; nutrition enhancer. Fragrance. Mainly used for fruit juice, cool drinks, nutritious drinks, etc.; Used as a biochemical reagent. Production method proteins such as gelatin, bone glue, casein, soybean epidermis, etc., hydrolyzed with hydrochloric acid, extracted with nitrosation method, refined and crystallized by resin chromatography.