Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of L-Histidine Monohydrochloride Monohydrate (H-His-OH·HCl·H2O) (CAS: 5934-29-2) with high quality. As one of the largest amino acids suppliers in China, Ruifu Chemical supplys amino acids and derivatives up to international standards, such as AJI, USP, EP, JP and FCC standard. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in L-Histidine Monohydrochloride Monohydrate, Please contact: alvin@ruifuchem.com
| Chemical Name |
L-Histidine Monohydrochloride Monohydrate |
| Synonyms |
L-Histidine HCL Monohydrate; H-His-OH·HCl Monohydrate; H-His-OH·HCl·H2O; L-Histidine Hydrochloride Monohydrate |
| Stock Status |
In Stock, Production Capacity 1000 Tons per Year |
| CAS Number |
5934-29-2 |
| Molecular Formula |
C6H9N3O2·HCl·H2O |
| Molecular Weight |
209.63 (191.62 anhy.) |
| Melting Point |
254℃(dec.)(lit.) |
| Sensitive |
Hygroscopic |
| Water Solubility |
Soluble in Water, 170 g/l 20℃ |
| Solubility |
Freely Soluble in Formic Acid. Practically Insoluble in Ethanol and in Ether. Dissolves in Dilute Hydrochloric Acid |
| Storage Temp. |
Sealed in Dry, Store at Room Temperature |
| COA & MSDS |
Available |
| Classification |
Amino Acid Derivatives |
| Brand |
Ruifu Chemical |
| Hazard Codes |
Xn |
RTECS |
MS3119000 |
| Risk Statements |
22-36/37/38 |
F |
10 |
| Safety Statements |
22-24/25-36/37-26 |
TSCA |
Yes |
| WGK Germany |
3 |
HS Code |
2922499990 |
| Items |
Inspection Standards |
Results |
| Appearance |
White Crystals or Crystalline Powder; Slightly Bitter Taste Sweet Taste |
Conforms |
| Identification |
Infrared Absorption Spectrum |
Conforms |
| Specific Rotation [α]20/D |
+8.9° to +9.5° (C=11 in 6N HCl) |
+9.3° |
| State of Solution (Transmittance) |
Clear and Colorless ≥98.0% |
98.3% |
| Chloride (Cl) |
16.66~17.08% |
16.9% |
| Sulfate (SO4) |
≤0.020% |
<0.020% |
| Ammonium (NH4) |
≤0.020% |
<0.020% |
| Iron (Fe) |
≤10ppm |
<10ppm |
| Heavy Metals (Pb) |
≤10ppm |
<10ppm |
| Arsenic (As2O3) |
≤1.0ppm |
<1.0ppm |
| Other Amino Acids |
Chromatographically Not Detectable |
Conforms |
| Loss on Drying |
≤0.20% |
0.08% |
| Residue on Ignition (Sulfated) |
≤0.10% |
0.05% |
| Assay |
98.5 to 101.0% (Titration: Anhydrous Basis) |
99.5% |
| pH Test |
3.5 to 4.5 (1.0g in 10ml of H2O) |
4.0 |
| Origin |
Non-Animal Source |
Conforms |
| Residual Solvents |
Conforms |
Conforms |
| Conclusion |
This Product by Inspection Accords with the Standard of AJI97 |
| Main Uses |
Amino Acids; Food Additives; Pharmaceutical Intermediates |
L-Histidine Monohydrochloride Monohydrate (H-His-OH·HCl·H2O) (CAS: 5934-29-2) Test Method
Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method.
Specific Rotation [α]20/D: Dried Sample, C=11, 6MOL/L HCl
State of Solution (Transmittance): 1.0g in 10ml of H2O, spectrophotometer, 430nm, 10nm cell thickness.
Chloride (Cl): Dried sample, 420mg, B-1
Sulfate (SO4): 1.2g, (1), ref: 0.50ml of 0.005mol/L H2SO4
Iron (Fe): 1.5g, (1), ref: 1.5ml of Iron Std. (0.01mg/ml)
Heavy Metals (Pb): 2.0g, (1), ref: 2.0ml of Pb Std. (0.01mg/ml)
Arsenic (As2O3): 2.0g, (1), ref: 2.0ml of As2O3 Std.
Other Amino Acids: Test Sample: 50μg, B-6-a, control: L-His HCl H2O 0.25μg
Loss on Drying: at 105℃ for 3 hours.
Assay: Dried sample, 100mg, (3), 3ml of formic acid, 0.1mol/L HCLO4 1ml=10.482mg C6H9N3O2·HCl·H2O
pH Test: 1.0g in 10ml of H2O
Package: Fluorinated Bottle, 25kg/bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
L-Histidine Monohydrochloride Monohydrate (H-His-OH·HCl·H2O) (CAS: 5934-29-2), non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.
Function:
1. L-Histidine is an extremely important component of amino acid infusion and comprehensive amino acid formulations for the treatment of gastric ulcers, anemia and allergies
2. L-Histidine can be used for prevention and treatment of anemia.
3. L-Histidine can reduce gastric acidity, ease gastrointestinal surgery pain, vomiting and stomach during pregnancy to reduce the burning sensation, inhibition of gastrointestinal ulcers caused by the autonomic nervous. For allergic diseases such as asthma, L-histidine also has effect.
4. L-Histidine can dilate blood vessels, lower blood pressure, angina, heart failure and other diseases for clinical practice.
Histidine is one of the essential raw materials for the synthesis of some pharmaceutical intermediates.
5. L-Histidine is a semi-essential amino acid that is particularly important for infants and animals. Can be used as biochemical reagents and pharmaceuticals, but also for the treatment of heart disease, anemia, rheumatoid arthritis and other drugs. Histidine is present in bananas, grapes, meat, poultry, milk and dairy products. In addition, histidine is also present in green vegetables, but less.
Application Area:
1.L-Histidine used as nutritional supplements
2.L-Histidine is an important component of amino acid transfusion, compound amino acid preparations.
3.L-Histidine Can be used for the treatment of gastric ulcer. Also used for biochemical studies.
4.Used as pharmaceutical raw materials and food additives.