Commercial Supply Tenofovir Related Intermediates:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl Isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
| Name | Tenofovir |
| Synonyms | (R)-PMPA; (R)-9-(2-Phosphonomethoxypropyl)Adenine |
| CAS Number | 147127-20-6 |
| CAT Number | RF-API07 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C9H14N5O4P |
| Molecular Weight | 287.22 |
| Melting Point | 276.0-280.0℃ |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White or Almost White Crystalline Powder |
| Assay / Analysis Method | 98.0%~102.0% (on anhydrous basis) |
| Solubility | Slightly Soluble in Water (0.1g in 100ml); Practically Insoluble in Methanol(0.01g in 100ml and over) |
| Identification UV | Absorbance at about 261nm |
| Identification HPLC | The retention time of the principal peak in the test sample should match with that of the standard |
| Sulphate Ash | ≤1.5% |
| Water (K.F) | ≤3.0% |
| Specific Optical Rotation | -19.0° ~ -23.0° (at 25℃ anhydrous basis) |
| PMPA Monoester Impurity | ≤1.5% (HPLC) |
| Any Single Max Impurity | ≤0.5% (HPLC) |
| Total Impurities | ≤3.0% (HPLC) |
| Enantiomeric Purity | ≤0.5% (HPLC) |
| 9-Propenyl Adenine | ≤75ppm (HPLC) |
| Test Standard | Enterprise Standard |
Package: Bottle, Aluminum foil bag, 25kg/Cardboard drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture.
Tenofovir (CAS: 147127-20-6) is an acyclic phosphonate nucleotide analogue and reverse-transcriptase inhibitor (NtRTI). It is used as an anti-HIV agent. Antiviral. Tenofovir disoproxil (Viread) is the first nucleotide analogue approved by the American FDA to treat HIV-1 infections. Tenofovir is a drug used for the treatment of chronic heptatitis B as well as prevention and treatment of HIV/AIDS. It inhibits the activity of HIV reverse transcriptase through competing with the natural substrate deoxyadenosine 5’-triphosphate, causing the termination of DNA chain.