Dextran 40 CAS 9004-54-0 CP2015 EP8.0 Specification

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Dextran 40 (CAS: 9004-54-0) with high quality. Ruifu Chemical has been supplying Dextran for over 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service. Purchase Dextran, Please contact: alvin@ruifuchem.com

Dextran 40 for injection
Dextranum 40 ad iniectabile
Definition
Mixture of polysaccharides, principally of the α-1,6-glucan tyupe.
Average relative molecular mass: about 40 000.
Production
It is obtained by hydrolysis and fractionation of dextrans produced by fermentation of sucrose using Leuconostoc mesenteroides strain NRRL B-512 = CIP 78.59 or substrains thereof (for example L. mesenteroides B-512F = NCTC 10817).
It is prepared in conditions designed to minimise the risk of microbial contamination.
Characters
Appearance: white or almost white powder.
Solubility: very soluble in water, very slightly soluble in ethanol (96 percent).
Identification
A. Specific optical rotation (2.2.7): +195 to +201 (dried substance).
Dissolve 1.0g in water R, heating on a water-bath, and dilute to 50.0ml with the same solvent.
B. Infrared absorption spectrophotometry (2.2.24).
Comparison: Dextran CRS.
C. Molecular-mass distribution (see Tests).
Tsets
Solution S. Dissolve 5.0g in distilled water R, heating on water-bath, and dilute to 50ml with the same solvent.
Appearance of solution. Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
Acidity or alkalinity. To 10ml of solution S add 0.1ml of phenolphthalein solution R. The solution remains colourless. Add 0.2ml of 0.01M sodium hydroxide. The solution is red. Add 0.4ml of 0.01M hydrochloric acid. The solution is colourless. Add 0.1ml of methyl red solution R. The solution is red or orange.
Nitrogen-containing substances: maximum 110ppm N.
Carry out the determination of nitrogen by sulfuric acid digestion (2.5.9), using 0.200g and heating for 2h. Collect the distillate in a mixture of 0.5ml of bromocresol green solution R, 0.5ml of methyl red solution R and 20ml of water R. Titrate with 0.01M hydrochloric acid. Not more than 0.15ml of 0.01M hydrochloric acid is required to change the colour of the indicator.
Residual solvents. Gas chromatography (2.2.28).
Internal standard: propanpl R.
Test solution. Dissolve 5g of the substance to be examined in 100ml of water R and distil. Collect the first 45ml of the distillate, add 1ml of a 25g/L solution of propanol R and dilute to 50ml with water R.
Reference solution. Mix 0.5mL of a 25g/L solution of anhydrous ethanol R, 0.5ml of a 25g/L solution of propanol R and 0.5ml of a 2.5g/L solution of methanol R and dilute to 25.0ml with water R.
Column:
- material: stainless steel;
- size: l=1.8m, ø=2mm;
- stationary phase: ethylvinylbenzene-divinylbenzene copolymer R (125-150μm).
Carrier gas: nitrogen for chromatography R.
Flow rate: 25mL/min.
Temperature:
- column: 190℃;
- ingection port: 240℃
- detector: 210℃
Detection: flame ionisation.
Injection: the chosen volum of each solution.
Limits:
- ethanol: not more than the area of the corresponding peak in the chromatogram obtained with the reference solution (0.5 percent);
- methanol: not more than the area of the corresponding peak in the chromatogram obtained with the reference solution (0.05 percent);
- sum of solvents other than ethanol, methanol and propanol: not more than the area of the peak due to the internal standard (0.5 percent, caclulated as propanol).
Molecular-mass distribution (2.2.39). The average molecular mass (M10) is 35 000 to 45 000. The average molecular mass of the 10 percent
high fraction is not greater than 110 000. The average molecular mass of the 10 percent low fraction is not less than 7000.
Heavy metals (2.4.8): maximum 10ppm.
12mL of solution S complies with test A. Prepare the reference solution using lead standard solution (1 ppm Pb)R.
Loss on drying (2.2.32): maximum 7.0 percent, determined on 0.200g by heating in an oven at 105±2℃ for 5 hours.
Sulfated ash (2.4.14): maximum 0.3 percent, determined on 0.50g.
Bacterial endotoxins(2.6.14): less than 10 IU/g.
Microbial contamination
TAMC: acceptance criterion 100 CFU/g (2.6.12).

Package: Bottle, Aluminium foil bag, 20kg/25kg/Cardboard drum, or according to customer's requirement.
Storage: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Incompatible with strong oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Risk Codes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S24/25 - Avoid contact with skin and eyes.
S37/39 - Wear suitable gloves and eye/face protection
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 2
RTECS HH9230000
FLUKA BRAND F CODES 3
TSCA Yes
HS Code 3913900090

Dextran 40 (CAS: 9004-54-0) is a complex polysaccharide that is widely used in scientific research and industrial applications. It is a highly branched polymer made up of glucose molecules and is produced by various bacterial strains. Dextran has been studied extensively for its properties and potential applications.
Dextran is mainly used to the production of Dextran 40 injection, compound dextran injection and other dextran derivative. It can also be used as fillers and excipients in lyophilized powder preparation.
Low molecular weight dextran is useful as a stabilizer, volume extender, lubricant, binding platform, and matrix component. Higher molecular weight dextrans have differing viscosities, aggregation and permeation properties.
Ruifu Chemical has been supplying Dextran for over 15 years.

Dextran is a water-soluble polymer composed of linear and branched polysaccharides linked by α-1,6-glycosidic bonds. The polymer consists of glucose molecules that are linked together by α-1,3, α-1,4, and α-1,6-glycosidic bonds. Dextran is produced by various bacterial strains, including Leuconostoc mesenteroides, Streptococcus thermophilus, Lactobacillus brevis, and others. Dextran was first identified in the 19th century by Louis Pasteur, who observed a slimy substance produced by bacteria.

Dextran has a high molecular weight and is a highly branched polymer. Its molecular weight can range from a few thousand to several million Daltons. It is a water-soluble polymer and exhibits good solubility in various solvents, including water, methanol, ethanol, and dimethyl sulfoxide. Dextran has a neutral charge and is often used as a source of carbon and energy for bacteria. Its physical and chemical properties vary depending on the degree of branching, molecular weight, and production method.

Dextran is produced by various bacterial strains through the fermentation of sugar sources, such as sucrose, glucose, or maltose. The synthesis of dextran involves the extracellular polymerization of glucose molecules through the action of dextransucrase enzymes. The resulting polymer is then exported out of the bacterial cell, where it forms a viscous gel-like substance. Dextran can be characterized by various analytical techniques, including gel permeation chromatography, NMR spectroscopy, and mass spectrometry.  

Dextran is a polysaccharide composed of glucose molecules linked together in a branched chain structure. It is produced by certain bacteria and is one of the most abundant polysaccharides in nature. Dextran has a wide range of scientific applications. It is used as a research tool in the fields of biochemistry, biomedicine, and food science. It has been used as a stabilizer, binder, and emulsifier in various food products. It is also used as a drug delivery system, as a protective agent in medical applications, and as a research tool in many areas of science. It has been used to study the structure and function of proteins, carbohydrates, and lipids. It has also been used to study the mechanisms of enzyme action and to investigate the effects of various drugs on biological systems.
Dextran has various applications in scientific experiments, including cell culture, protein purification, and drug delivery. It is often used as a stabilizer for proteins and enzymes and as a cryoprotectant to prevent freezing damage. Dextran can also be used as a molecular weight marker in gel electrophoresis and as a filler material in chromatography columns. 

Dextran 40 (CAS: 9004-54-0) is a polysaccharide composed of glucose molecules linked together in a branched chain structure. The branched structure of dextran gives it a large surface area, which allows it to interact with other molecules in the environment. This interaction is the basis of its mechanism of action. It binds to molecules such as proteins, carbohydrates, and lipids, and can act as a protective agent or as a drug delivery system.

Dextran 40 (CAS: 9004-54-0) has a range of biochemical and physiological effects. It can act as a protective agent, binding to molecules such as proteins, carbohydrates, and lipids, and preventing them from being broken down or denatured. It can also act as a drug delivery system, allowing drugs to be released into the body in a controlled manner. It has also been shown to have anti-inflammatory and anti-microbial effects, as well as stimulating the immune system.