Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate (CAS: 143878-29-9) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Prucalopride Succinate Intermediates, Please contact: alvin@ruifuchem.com
| Chemical Name |
Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate |
| Synonyms |
Methyl 4-(Acetylamino)-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylate; Prucalopride Intermediate A; Prucalopride Succinate Intermediate A; Prucalopride Succinate Impurity N; Prucalopride Impurity 18 |
| Stock Status |
In Stock, Commercial Production |
| CAS Number |
143878-29-9 |
| Molecular Formula |
C12H12ClNO4 |
| Molecular Weight |
269.68 g/mol |
| Boiling Point |
492.0±45.0℃ at 760 mmHg |
| Density |
1.400±0.06 g/cm3 |
| Refractive Index n20/D |
1.6 |
| COA & MSDS |
Available |
| Shipping |
Normal |
| Origin |
Shanghai, China |
| Category |
Intermediate of Prucalopride Succinate (CAS: 179474-85-2) |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White to Off-White Solid |
Off-White Solid |
| Purity / Analysis Method |
>98.0% (HPLC) |
99.19% |
| Loss on Drying |
<0.50% |
0.15% |
| Single Impurity |
<1.00% |
Complies |
| Total Impurities |
<2.00% |
Complies |
| Infrared Spectrum |
Conforms to Structure |
Complies |
| Proton NMR Spectrum |
Conforms to Structure |
Complies |
| Conclusion |
The product has been tested & complies with the given specifications |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
List of Solvents Used in Manufacturing
DMF, Toluene, Ethyl Acetate
(1) Determination requirement: The relevant substances were determined by area normalization method
(2) Chromatographic conditions
Column: C18 reverse column, 4.6*250mm, 5μm
Column temperature: 40℃
Flow rate: 1.0ml/min
Detection wavelength: 254nm
Sample size: 10μL
Mobile phase:
Mobile phase B: acetonitrile
Mobile phase A: phosphate buffer (1.36g potassium dihydrogen phosphate was dissolved in 1L water; Adjust PH to 6.5 with potassium hydroxide, filter with 0.22 micron filter membrane, ultrasonic degassing)
Mobile phase ratio: 55-45
Dilute release agent: acetonitrile
Blank control: same diluent
(3) Sample configuration
Test solution: Take an appropriate amount of the product, weigh it accurately, dissolve it with a dissolving solvent and dilute it into a solution containing -mg per -ml. Filter it with a 0.22 micron filter membrane and use it as the test solution
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Methyl 4-Acetamido-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate (CAS: 143878-29-9) is an intermediate of Prucalopride Succinate (CAS: 179474-85-2). Prucalopride Succinate is approved for the treatment of chronic constipation in Europe. Prucalopride Succinate, a first-in-class dihydrobenzofurancarboxamide, is a selective serotonin (5- HT4) receptor agonist. The drug, marketed under the brand name Resolor®, possesses enterokinetic activity and was developed by the Belgian-based pharmaceutical firm Movetis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation, triggering the central propulsive force for defecation.
