Manufacturer Supply, High Purity, Commercial Production
| Chemical Name | Candesartan Cilexetil |
| Synonyms | TCV-116; 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-Carboxylate |
| CAS Number | 145040-37-5 |
| CAT Number | RF-PI1891 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C33H34N6O6 |
| Molecular Weight | 610.66 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystalline Powder |
| Identification HPLC | The retention time of the major peak in the chromatogram of the sample corresponds to that in the chromatogram obtained with the standard |
| Identification IR | IR infrared absorption spectrum is identical to that of Candesartan Cilexetil reference standard |
| Clarity and Color Solution | Solution in chloroform at 5% is clear and colourless |
| Purity / Analysis Method | >99.0% (HPLC) |
| Melting Point | 155.0~160.0℃ |
| Loss on Drying | <0.30% |
| Residue on Ignition | <0.10% |
| Heavy Metals | <10ppm |
| Arsenic (As) | <1ppm |
| Particle Size Distribution | 90% <30 μm |
| Organic Impurities | by HPLC |
| Ethyl Candesartan | <0.15% |
| Desethyl Candesartan | <0.15% |
| N2-Ethyl Candesartan Cilexei | <0.15% |
| Any Unknown Impurity | <0.15% |
| Total Impurities | <0.60% |
| Assay by Potentiometry | 99.0~101.0% of C33H34N6O6, calculated on the anhydrous substance |
| Organic Volatile Impurity | |
| Methano | <0.30% |
| Ethanol | <0.50% |
| Diethyl Ether | <0.50% |
| Aceton | <0.50% |
| Dichloromethan | <0.06% |
| Dimethylformamide | <0.088% |
| Microbiological Contarnination | |
| Total Aerobic Microbial Count | <1000cfu/g |
| Moulds & Yeasts | <100cfu/g |
| E.Coli | Absent |
| Salmonella | Absent |
| Test Standard | Enterprise Standard |
| Usage | API; Antihypertensive Agent |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension. Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.