Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) (CAS: 25561-30-2) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. Please contact: alvin@ruifuchem.com
| Chemical Name |
N,O-Bis(trimethylsilyl)trifluoroacetamide with Trimethylchlorosilane |
| Synonyms |
BSTFA; 99% BSTFA + 1% TMCS |
| CAS Number |
25561-30-2 |
| CAT Number |
RF-PI2128 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C8H18F3NOSi2 |
| Molecular Weight |
257.40 |
| Melting Point |
-10℃ |
| Boiling Point |
45.0~50.0℃/14 mm Hg(lit.) |
| Specific Gravity (20/20) |
0.97 g/mL(lit.) |
| Sensitive |
Moisture Sensitive, Heat Sensitive |
| Water Solubility |
Hydrolyses |
| Hydrolytic Sensitivity |
8: Reacts Rapidly with Moisture, Water, Protic Solvents |
| Solubility |
Very Soluble in Dichloromethane, Benzene, Ether |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
Colorless to Light Yellow Clear Liquid |
| Typicaly (BSTFA) |
>99.0% (GC) (including Chlorotrimethylsilane) |
| Refractive Index N20/D |
1.3825~1.3949 |
| Chlorotrimethylsilane (TMCS) |
About 1% |
| Infrared Spectrum |
Conforms to Structure |
| Proton NMR Spectrum |
Conforms to Structure |
| Test Standard |
Enterprise Standard |
| Usage |
Silicon Compounds; GC Derivatization Reagents |
Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) (CAS: 25561-30-2) is used for synthesis of pharmaceutical intermediates. Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties. BSTFA with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). BSTFA is similar to BSA in specificity of modification and there are several studies which have used both reagents. One study found BSTFA superior to BSA in product stability and yield of derivative. Another study compared several trimethylsilyl donors for end-capping of silica and observed that BSTFA was more reactive than BSA but less reactive than TMCim. Both BSA and BSTFA were used to prepare trimethylsilyl derivatives of pyrimidines and purines. BSTFA is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. BSTFA is an important pharmaceutical intermediate, which can reduce the polarity of hydroxy-containing compounds and increase their volatility, making samples more suitable for GC analysis. As a mild neutral silanylation reagent, it not only has high reactivity, good selectivity, but also has the advantages of high reaction yield and simple post-treatment. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides.