Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Betulin (CAS: 473-98-3) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Betulin, Please contact: alvin@ruifuchem.com
| Chemical Name |
Betulin |
| Synonyms |
Betulinol; Betulinic Alcohol; Betula Camphor; Birch Bark Extract; Betulol; Trochol; Lup-20(29)-ene-3β,28-diol; (3β)-Lup-20(29)-ene-3,28-diol |
| Stock Status |
In Stock, Commercially Manufactured |
| CAS Number |
473-98-3 |
| Molecular Formula |
C30H50O2 |
| Molecular Weight |
442.73 g/mol |
| Melting Point |
251.0~257.0℃ |
| Density |
1.017g/cm3 |
| Specific Rotation [a]20/D |
+17.0° to +21.0° (C=2 in Pyridine) |
| Stability |
Hygroscopic |
| Storage Temp. |
Cool & Dry Place (2~8℃) |
| COA & MSDS |
Available |
| Category |
Plant Extracts |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White to Off-White Powder |
White Powder |
| Betulin Purity |
>98.0% (HPLC) |
99.15% |
| Melting Point |
251.0~257.0℃ |
Complies |
| Loss on Drying |
<2.00% (2g/105℃/5hrs) |
0.13% |
| Ash |
<0.50% (2g/600℃/5hrs) |
0.10% |
| Bulk Density |
0.25~0.45 g/ml |
Complies |
| Particle Size |
98% Pass 80 Mesh |
Complies |
| Heavy Metals (Pb) |
≤10ppm |
<10ppm |
| Arsenic |
≤1ppm |
<1ppm |
| Residual Solvent |
≤1000ppm |
Complies |
| Microbiological Tests |
|
|
| Total Plate Count |
≤1000CFU/g |
Complies |
| Yeast & Mold |
≤100CFU/g |
Complies |
| Escherichia Coli |
Negative |
Negative |
| Infrared Spectrum |
Conforms to Structure |
Complies |
| Proton NMR Spectrum |
Conforms to Structure |
Complies |
| Solubility in Pyridine 50mg/ml |
Yellow to Brown Clear to Slighty Hazy |
Pass |
| Conclusion |
The product has been tested & complies with the specifications |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R68/20/21/22 -
R68 - Possible risk of irreversible effects
Safety Description
S36/37 - Wear suitable protective clothing and gloves.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
RTECS OK5755000
HS Code 2906199090
Betulin (CAS: 473-98-3) is an extract from bark of the white birch tree, which has been known since the 18th century and is chemically defined. Betulin was discovered by German-Russian chemist Johann Tobias Lowitz. He was the first scientist to study and characterise betulin, and in doing was one of the first to isolate an active plant ingredient. Betulin is a substance of pure plant origin that gives the birch bark its typical white colour. Betulin protects birch trees from environmental effects, such as extreme temperatures, pest infestations and solar radiation.
Betulin is white crystalline powder, soluble in alcohol, chloroform and benzene, slightly soluble in cold water, petroleum ether.
Currently Betulin is obtained mainly through direct extraction, and mainly by solvent reflux extraction and recrystallization purification Specifically: 1. Extract betulin from ethanol solution. After heating reflux about 5h, the extract is vacuum distillated and recrystallized with ethanol for 2 to 3 times with ethanol to obtain crude product of betulin. 2. The crude product was recrystallized from methanol/chloroform (1: 1) (every 80g crude product requires 300mL methanol/chloroform solution).The mixture is allowed to stand overnight and then suction filtered to obtain white needle-like betulin. 3. Ultrasonic treatment for 20min when refluxing is carried out, and the extraction yield and product purity of betulin can be improved through the destruction of bark organization. 4. The optimum conditions of supercritical CO2 fluid extraction are as follows: the amount of modifier was 115mL/(g birch bark powder); extraction pressure is 20MPa; extraction temperature was 55℃; liquid CO2 flow rate was 10kg/h.