Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 4-(Methylthio)phenylacetic Acid (CAS: 16188-55-9) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com
| Chemical Name |
4-(Methylthio)phenylacetic Acid |
| Synonyms |
4-Methylthiophenylacetic Acid; 2-(4-(Methylthio)phenyl)acetic Acid; 2-[4-(Methylsulfanyl)phenyl]acetic Acid; 4-(Methylthio)benzeneacetic Acid |
| CAS Number |
16188-55-9 |
| CAT Number |
RF-PI1183 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C9H10O2S |
| Molecular Weight |
182.24 |
| Melting Point |
96.0~99.0℃ (lit.) |
| Boiling Point |
337.4±25.0℃ (lit.) |
| Density |
1.23±0.10 g/cm3 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White to Light Yellow Powder |
| Purity / Analysis Method |
>98.0% (GC) |
| Purity / Analysis Method |
>98.0% (Neutralization Titration) |
| Melting Point |
96.0~99.0℃ |
| Loss on Drying |
<1.00% |
| Residue on Ignition |
<0.50% |
| Total Impurities |
<2.00% |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Etoricoxib (CAS: 202409-33-4) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
4-(Methylthio)phenylacetic Acid (CAS: 16188-55-9) is the key intermediate for the preparation of Etoricoxib (CAS: 202409-33-4). Etoricoxib is a kind of highly selective cyclooxygenase-2 (COX-2) inhibitors developed by the Merck company with the chemical name being 5-chloro-6'-methyl-3-4-(methanesulfonamide) phenyl]-2, 3'-bipyridine. Etoricoxib has a unique chemical structure that is methylsulfonyl group. The introduction of this group can not only increase the selectivity for COX-2 drugs, but also does not produce sulfa drugs and cross-allergic reactions. Etoricoxib is widely used in treatment of osteoarthritis (OA), rheumatoid arthritis, ankylosing spondylitis, chronic low back pain, acute gouty arthritis, primary dysmenorrhea and postoperative pain, and other diseases.