Manufacturer Supply, High Purity, Commercial Production
| Chemical Name |
2-(p-Tolyl)benzoic Acid |
| Synonyms |
4'-Methylbiphenyl-2-Carboxylic Acid; 2-(4-Methylphenyl)benzoic Acid |
| CAS Number |
7148-03-0 |
| CAT Number |
RF-PI1884 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C14H12O2 |
| Molecular Weight |
212.25 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White to Very Pale Yellow Crystal or Powder |
| Purity / Analysis Method |
>98.0% (GC) |
| Melting Point |
148.0~152.0℃ |
| Loss on Drying |
<1.00% |
| Total Impurities |
<2.00% |
| Solubility in Methanol |
Almost Transparency |
| Proton NMR Spectrum |
Conforms to Structure |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate for Sartan APIs; Telmisartan
|
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
2-(p-Tolyl)benzoic Acid (CAS: 7148-03-0) is an important intermediate for sartan APIs. Sartan antihypertensive drugs are a new type of drugs commonly used in clinical treatment of hypertension, and are an abbreviation of angiotensin II receptor antagonist. Relatively speaking, these drugs have a higher antihypertensive effect and fewer side effects. 1. Losartan: This is the earliest Sartan antihypertensive drug put into use in clinical practice, and it can be said to be a representative of this type of drug. Generally, patients need to choose an appropriate dose to take it once a day. After taking it for 5 consecutive days, the blood pressure of the patient will obviously decrease. Another function of this medicine is to help patients excrete excessive uric acid from the urine. Therefore, in general, it is ideal and safer to take this medicine when patients with hypertension are accompanied by symptoms of increased uric acid. In recent years, in the clinic, losartan combined with diuretic hydrochloride is made into a compound tablet called Hyzaar. 2. Valsartan: The effect of this antihypertensive drug is relatively rapid, and the onset time is relatively early, and generally patients need to take it once a day. 3. Irbesartan: The commercial name of this sartan antihypertensive drug is Ambovir Generally, patients need to take 1 tablet per day. Relatively speaking, oral absorption is good, and the effect is not affected by food. 4. Telmisartan, is a long-acting antihypertensive drug. It has only been used in clinical practice in recent years. It has a positive effect and low adverse reactions. It is taken once a day.