Olaparib and Related Intermediates:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Chemical Name |
1-(Cyclopropylcarbonyl)piperazine Hydrochloride |
| CAS Number |
1021298-67-8 |
| CAT Number |
RF-PI452 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C8H14N2O·HCl |
| Molecular Weight |
190.67 |
| Melting Point |
175.0 to 179.0℃ |
| Solubility |
Soluble in Water |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White Powder |
| Purity |
≥99.0% |
| Moisture (K.F) |
≤0.50% |
| Single Impurity |
≤0.50% |
| Total Impurities |
≤1.0% |
| Test Standard |
Enterprise Standard |
| Usage |
Pharmaceutical Intermediate |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
1-(Cyclopropylcarbonyl)piperazine Hydrochloride (CAS: 1021298-67-8) is used as a pharmaceutical intermediate. It can be used as a intermediate of Olaparib (CAS: 763113-22-0). Olaparib is a potent inhibitor of both PARP-1 and PARP-2 and is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition. Olaparib was approved in 2014 by FDA for treating advanced ovarian cancer.