Factory Supply Posaconazole Related Intermediates, Commercial Production
Posaconazole CAS 171228-49-2
Posaconazole Intermediate POA CAS 149809-43-8
Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
Diethyl L-(+)-Tartrate CAS 87-91-2
| Chemical Name |
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine |
| Synonyms |
4-[4-(4-Aminophenyl)piperazin-1-yl]phenol |
| CAS Number |
74853-08-0 |
| CAT Number |
RF-PI292 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C16H19N3O |
| Molecular Weight |
269.34 |
| Melting Point |
>180℃(dec.) |
| Density |
1.237g/cm3 |
| Shipping Condition |
Under Ambient Temperature |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
Pale Brown to Off White Powder |
| Purity |
≥99.0% |
| Loss on Drying |
≤0.50% |
| Residue on Ignition |
≤0.20% |
| Single Impurity |
≤0.50% |
| Total Impurities |
≤1.0% |
| Heavy Metals (as Pb) |
≤20ppm |
| Residual Solvents |
Meet the specifications |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Posaconazole (CAS 171228-49-2) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine (CAS 74853-08-0) is the intermediate of Posaconazole (CAS 171228-49-2). Posaconazole is a triazole antifungal drug marketed in the United States by Schering-Plough under the trade name Noxafil. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase.