Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of WZ4002 (CAS: 1213269-23-8) with high quality. Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase WZ4002 or other products, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | WZ4002 |
| Synonyms | WZ-4002; WZ4002 (HBr); CS-166; N-{3-[(5-Chloro-2-{[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)oxy]phenyl}acrylamide |
| CAS Number | 1213269-23-8 |
| Molecular Formula | C25H27ClN6O3 |
| Molecular Weight | 494.97 g/mol |
| Density | 1.314 |
| Solubility | ≥24.7 mg/mL in DMSO; Insoluble in H2O; Insoluble in EtOH |
| Storage Temperature | Store Long-Term at -20℃, Protected From Light and Moisture |
| Stability | 2 Years When Properly Store |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Application(s) | EGFR Inhibitor |
| Research Area | Lung Cancer |
| Caution | Not For Human Use. For Research Use Only. |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Off-White Solid Powder | Off-White Solid Powder |
| Purity / Analysis Method | >98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Bottle, Aluminium foil bag, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store long-term at -20℃, store away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
For Research Use Only! Not For Use in Humans!
None of the products will be supplied to countries in which this could be in conflict with the existing patents. However the final responsibility lies with the buyer.
If our products infringe the rights of your company, please contact us to delete.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
WZ4002 (CAS: 1213269-23-8) is a novel, mutation-selective EGFR inhibitor with an IC50 of 2 nM/8 nM when acting on EGFR(L858R)/(T790M); it has no inhibitory effect on ERBB2 phosphorylation (T798I). WZ4002 is a potent inhibitor of EGFR, exhibiting an IC50 = 2 nM. This induces apoptosis in the cell due to the blocking of signal transduction from EGFR. WZ4002 is effective in the treatment of lung adenocarcinomas due to EGFR (epidermal growth factor receptor) mutations.