Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Trimethyl Orthoformate (TMOF) (CAS: 149-73-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Trimethyl Orthoformate, Please contact: alvin@ruifuchem.com
| Chemical Name | Trimethyl Orthoformate |
| Synonyms | TMOF; Trimethoxymethane; Methyl Orthoformate; Orthoformic Acid Trimethyl Ester; Perma-Flo OF |
| Stock Status | In Stock, Production Capacity 5000 Tons per Year |
| CAS Number | 149-73-5 |
| Molecular Formula | C4H10O3 |
| Molecular Weight | 106.12 g/mol |
| Melting Point | -53℃ |
| Boiling Point | 100℃ |
| Flash Point | 15℃ |
| Specific Gravity (20/20) | 0.97 |
| Refractive Index n20/D | 1.38 |
| Sensitive | Moisture Sensitive |
| Solubility | Soluble in Ether, Benzene, Alcohol |
| COA & MSDS | Available |
| Sample | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Colorless Clear Liquid | Colorless Clear Liquid |
| Trimethyl Orthoformate | >99.5% (GC) | 99.63% |
| Water by Karl Fischer | <0.05% | 0.026% |
| Density (20℃) | 0.968~0.972 | Complies |
| Refractive Index n20/D | 1.377~1.380 | Complies |
| Methyl Formate | <0.20% | 0.042% |
| Methanol | <0.40% | 0.012% |
| Color (APHA) | <20 | 10 |
| Infrared Spectrum | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Fluorinated Bottle, 25kg/Drum, 180kg/Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Away from fire and open flame; Store and transport Isolation with oxidant to avoid sun exposure.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes R11 - Highly Flammable
R36 - Irritating to the eyes
Safety Description S9 - Keep container in a well-ventilated place.
S16 - Keep away from sources of ignition.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S29 - Do not empty into drains.
UN IDs UN 3272 3/PG 2
WGK Germany 1
RTECS RM6650000
TSCA Yes
HS Code 2942000000
Hazard Class 3
Packing Group II
Trimethyl Orthoformate (TMOF) (CAS: 149-73-5) is used as an organic synthesis intermediate, pharmaceutical intermediate. Used as a versatile reagent and intermediate in organic synthesis.
Trimethyl Orthoformate is a highly reactive compound that can be used in a variety of reactions, including acylation, alkylation, and condensation reactions. It is commonly used as a protecting group for aldehydes and ketones, and as a source of methyl groups in reactions that require them.
Trimethyl Orthoformate is used as a protecting group for aldehydes in organic synthesis, as an additive in polyurethane coatings and as a dehydrating agent in the preparation of surface modified colloidal silica nanoparticles. It is also used as a chemical intermediate in the preparation of vitamin B1 and sulfa drugs.
In the pharmaceutical industry for the production of vitamin B1, vitamin A, sulfadiazine, pipemidic acid and antibacterial agents, among them, the consumption of vitamin B1 accounted for the largest proportion of methyl formate. It is also used in the dye and fragrance industry. In the aspect of coating, it is used as a dehydrating agent to prevent hardening of polyurethane or epoxy coating due to hydration. It is used as an intermediate in the production of vitamin B1, sulfonamides, antibiotics and other drugs, and is a raw material for spices and pesticides and an additive for polyurethane coatings.
However, Trimethyl Orthoformate is also highly flammable and can be dangerous if not handled properly. It is important to follow proper safety procedures when working with this compound, such as wearing protective clothing and working in a well-ventilated area.
A skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react with oxidizing materials. Hazardous to prepare. To fight fire, use CO2, fog, haze. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
Flammability hazard characteristics: In case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent.