Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of tert-Butyldimethylsilyl Chloride (TBDMSCl) (CAS: 18162-48-6) with high quality, production capacity 1400 tons per year. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase TBDMSCl, Please contact: alvin@ruifuchem.com
| Chemical Name |
tert-Butyldimethylsilyl Chloride |
| Synonyms |
TBDMSCl; TBDMS-Cl; TBSCl; TBS-Cl; tert-Butyldimethylchlorosilane; tert-Butylchlorodimethylsilane; Chlorodimethyl-tert-butylsilane; tert-Butyl(dimethyl)silane Chloride; Chloro-tert-Butyldimethyl-Silane |
| CAS Number |
18162-48-6 |
| Stock Status |
In Stock, Mass Production |
| Molecular Formula |
C6H15ClSi |
| Molecular Weight |
150.72 |
| Melting Point |
86.0~90.0℃(lit.) |
| Boiling Point |
124.0~126.0℃ @ 760mmHg |
| Density |
0.87 g/mL at 20℃(lit.) |
| Refractive Index |
n20/D 1.46 |
| Sensitive |
Moisture Sensitive |
| Solubility |
Soluble in Dichloromethane, Ether, Toluene, Benzene |
| Storage Temp. |
Cool and Dry (≤10℃) |
| COA & MSDS |
Available |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White Crystalline Powder |
| Purity / Analysis Method |
>99.0% (GC) |
| Melting Point |
86.0~90.0℃ |
| T-Butyldimethylsilanol |
<0.30% (GC) |
| Proton NMR Spectrum |
Conforms to Structure |
| Solubility in CHCL3 |
Colorless, Clear, 25mg/ml Pass |
| Attention |
Moisture sensitive. Protect from light and Store in a cool dry place (≤10℃) |
| Test Standard |
Enterprise Standard |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Moisture sensitive. Store in sealed containers at cool and dry (≤10℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.
Risk Codes
R22 - Harmful if swallowed
R35 - Causes severe burns
R40 - Limited evidence of a carcinogenic effect
R34 - Causes burns
R10 - Flammable
R19 - May form explosive peroxides
R11 - Highly Flammable
R67 - Vapors may cause drowsiness and dizziness
R65 - Harmful: May cause lung damage if swallowed
R63 - Possible risk of harm to the unborn child
R48/20 -
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R45 - May cause cancer
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
R37 - Irritating to the respiratory system
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S46 - If swallowed, seek medical advice immediately and show this container or label.
S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S25 - Avoid contact with eyes.
S16 - Keep away from sources of ignition.
S28 - After contact with skin, wash immediately with plenty of soap-suds.
S27 - Take off immediately all contaminated clothing.
S33 - Take precautionary measures against static discharges.
S29 - Do not empty into drains.
S53 - Avoid exposure - obtain special instructions before use.
S36/37 - Wear suitable protective clothing and gloves.
UN IDs UN 2925 4.1/PG 2
WGK Germany 2
RTECS VV2000000
FLUKA BRAND F CODES 10-21
TSCA Yes
HS Code 2931900090
Hazard Note Flammable/Corrosive/Moisture Sensitive
Hazard Class 4.1
Packing Group III
tert-Butyldimethylsilyl Chloride (TBDMSCl) (CAS: 18162-48-6) is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. tert-Butyldimethylsilyl Chloride is a chemical used to protect alcohols during organic synthesis. It acts as a versatile protecting reagent for amines, amides and alcohols.
TBDMSCl is a sterically hindered organosilicon protective agent, which is widely used in the synthesis of original drugs. It is used as a protective group for hydroxyl in the synthesis of ribonucleosides, and is also an oxidant and decyanide.
Auxiliary raw materials for the synthesis of prostaglandins, certain antibiotics, hypolipidemic drugs lovastatin and simvastatin used as pharmaceutical intermediates and used in organic synthesis, as a hydroxyl protective agent in organic synthesis used in drug intermediates and organic synthesis, is a sterically hindered silicone protective agent, widely used in the synthesis of original drugs. It is used as a protective group for the hydroxyl group in the synthesis of ribonucleosides, and is also an oxidant and decyanating agent. silanizer. As a hydroxyl protective agent in organic synthesis, derivatization reagents are used for analysis and preparation. Protect tertiary alcohols. Reacts with alcohols to form silicone ether. Determination of the conformation of cholesterol derivatives.
Definition ChEBI: Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.
tert-Butyldimethylsilyl Chloride (TBDMSCl) (CAS: 18162-48-6) was synthesized by the reaction of tert-butyllithium with dichlorodimethylsilane.
The pentane solution of dichlorodimethylsilane was cooled to 0℃, and the pentane solution of tert-butyllithium was added dropwise with stirring under nitrogen. The temperature was maintained at 0℃, stirred for 1.5 h and then heated to 25℃, and the reaction was continued for 48 h. Distillation, collect 125℃ (97.5kPa) fractions, stand to solidify, and obtain tert-butyldimethylsilyl chloride. Yield 70%.