Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Tadalafil Intermediate (CAS: 171752-68-4) with high quality. Ruifu Chemical has been supplying pharmaceutical intermediates more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Tadalafil Intermediates, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride |
| Synonyms | Tadalafil Intermediate; Methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride; cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride; Tadalafil N-2Intermediate; Tadalafil Impurity 1 Hydrochloride |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 171752-68-4 |
| Molecular Formula | C20H19ClN2O4 |
| Molecular Weight | 386.83 g/mol |
| Melting Point | 239.0-241.0℃ |
| Stability | Hygroscopic |
| Storage Condition | Store Under Inert Gas (Nitrogen or Argon) at 2-8℃ |
| Shipping Conditions | Ambient |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
Pharmaceutical Intermediates; Tadalafil Intermediates |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White to Pale Yellow Powder | Off-White Powder |
| Related Substances | (Excluded A+C) | |
| Single Impurity | ≤0.50% | 0.170% |
| Total Impurities | ≤1.00% | 0.278% |
| Isomer | ||
| A (1R 3S) | ≤0.10% | ≤0.019% |
| B (1S 3S) | ≤0.10% | Not Detected |
| C (1S 3R) | ≤2.00% | ≤0.722% |
| Loss on Drying | ≤0.50% | 0.04% |
| Residue on Ignition | ≤0.20% | 0.08% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Assay / Analysis Method | ≥98.0% (HPLC) (on Dried Basis) | 98.6% |
| 1H NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application | Intermediate of Tadalafil (CAS: 171596-29-5) | |
Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Store under inert gas. Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride is an intermediate of Tadalafil (CAS: 171596-29-5). Tadalafil (sold under the brand name Cialis among others) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men.