Factory Supply Posaconazole Related Intermediates, Commercial Production
Posaconazole CAS 171228-49-2
Posaconazole Intermediate POA CAS 149809-43-8
Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
Diethyl L-(+)-Tartrate CAS 87-91-2
| Name |
Posaconazole Intermediate POA |
| Synonyms |
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester; (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate |
| CAS Number |
149809-43-8 |
| CAT Number |
RF-PI291 |
| Stock Status |
In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula |
C21H21F2N3O4S |
| Molecular Weight |
449.47 |
| Density |
1.40 |
| Shipping Condition |
Shipped Under Ambient Temperature |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White to Grey White Powder |
| Identification |
IR In accordance with the standard |
| Melting Point |
100.0-102.0℃ |
| Specific Rotation [a]20/D |
-40.0° to -48° (C=1, CHCl3) |
| Loss on Drying |
≤0.50% |
| Residue on Ignition |
≤0.20% |
| Heavy Metals |
≤20ppm |
| Related Substances |
|
| Major Impurity |
≤0.40% |
| POA-Enantiomer |
≤0.10% |
| POA-Diastereomer |
≤0.20% |
| Individual Unknown Impurity |
≤0.20% |
| Total Impurities |
≤1.0% |
| Purity |
≥99.0% |
| Assay |
98.0%~102.0% (anhydrous substance) |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Posaconazole (CAS 171228-49-2) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester (CAS 149809-43-8) is the Intermediate of Posaconazole (CAS 171228-49-2). Posaconazole is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.