N,N-Dimethylacetamide (DMAc) CAS 127-19-5 Purity ≥99.80% (GC) Factory

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N,N-Dimethylacetamide (DMAc) (CAS: 127-19-5) with high quality, commercially manufactured. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase N,N-Dimethylacetamide, Please contact: alvin@ruifuchem.com

Package: Bottle, 25kg/Drum, 180kg/Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Avoid sun exposure, not close to the fire source, handling should be taken lightly, according to the provisions of the transport of toxic substances.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery. 

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Hazard Symbols T - Toxic
Risk Codes
R11 - Highly Flammable
R20/22 - Harmful by inhalation and if swallowed.
R61 - May cause harm to the unborn child
R20/21 - Harmful by inhalation and in contact with skin.
R36 - Irritating to the eyes
Safety Description
S16 - Keep away from sources of ignition.
S24 - Avoid contact with skin.
S53 - Avoid exposure - obtain special instructions before use.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36 - Wear suitable protective clothing.
S28 - After contact with skin, wash immediately with plenty of soap-suds.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS AB7700000
FLUKA BRAND F CODES 3-10
HS Code 2924199090
Toxicity LD50 orally in rats: 5.4 ml/kg (Bartsch)

N,N-Dimethylacetamide (DMAc) (CAS: 127-19-5) is a highly polar aprotic solvent, micro ammonia odor, very strong dissolving power, soluble wide, miscible with water, aromatics, esters, ketones, alcohols, ether, benzene and chloroform and other arbitrary and enable activation of molecular compounds. It is widely used as a solvent and a catalyst. The solvent, with high boiling point, flash point, thermal stability and chemical stability of the solvent, is used for polyacrylonitrile spinning solvent, synthetic resin and natural resins, formic acid vinyl ester resin, vinyl pyridine copolymer and aromatic carboxylic acid. The catalyst can be used in the process of urea heating to produce the reaction of cyanide, sodium halide and metal cyanide to produce the reaction of alkyl acetylene, organic halide and isocyanate.  
N,N-Dimethylacetamide is used as a polar solvent in organic synthesis as well as in reactions involving strong bases such as sodium hydroxide. It is also used as a solvent for fibers like polyacrylonitrile, spandex, as an excipient in drugs viz. vumon, busulfex and in the adhesive industry. It finds application as a reaction medium in the production of pharmaceuticals, agrochemicals, dyes and plasticizers. It is widely used in polymer industry due to its high solving power for high molecular-weight polymers and synthetic resins. It plays an important role as a catalyst in various reactions viz. cyclization, halogenation, cynidation, alkylation and dehydrogenation and increases the yield of main products. It is also used as an extracting agent for oil and gases, in paint removers, in the production of photo-resist stripping compounds and as booster solvent in coatings.
DMAc is a synthetic organic compound that is produced from a reaction of dimethylamine and acetic acid or acetic anhydride. DMAc is commonly associated with many industrial uses, either as a starting material or an intermediate. DMAc is a good solvent that is used in polymer dissolution, especially in the fiber industry.
DMAc is an important industrial solvent for polyacrylonitrile, vinyl resins, cellulose derivatives, styrene polymers and linear polyesters. It is also used in all analytical laboratories as a major component of mobile phase in High Performance Liquid Chromatography (HPLC) and in Liquid Chromatography - Mass Spectrometry (LC-MS).  
N,N-Dimethylacetamide is primarily used as an industrial solvent and intermediate in the manufacture of pharmaceuticals, fine chemicals, agrochemicals, dyes, polymers, and resins. It is also used as a spinning solvent in the production of fibers of various polymers, including acrylic, polyurethane, polyurea copolymer, and meta-aramid. Moreover, this aprotic dipolar solvent is also used in X-ray and photographic products and in the production of polyimide films.   

N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.

Moderately toxic by skin contact, inhalation, intravenous, and intraperitoneal routes.  Mildly toxic by ingestion.  Experimental teratogenic and reproductive effects.  A skin and eye irritant.  Less toxic than dimethylformamide.  Mutation data reported.  Combustible when exposed to heat and flame.  A moderate explosion hazard.  Violent reaction with halogenated compounds (e.g., carbon tetrachloride, hexachlorocyclohexane) when heated above 9OOC.  Iron powder catalyzes the reaction so that it initiates at 71OC.  When heated to decomposition it emits toxic fumes of NOx.

Incompatible with carbon tetrachloride and other halogenated compounds.  Unsaturated aliphatic compounds are easily soluble in this product, but the solubility of saturated aliphatic compounds in this product is very small.  This product is less hydrolytic, but it can accelerate hydrolysis in the presence of acid and alkali.  This product has good stability and does not decompose during distillation.  It can react with strong bases to form acetate and alkylamine.  In the presence of protons, heating can be alcoholized.

Workers who are often exposed to dimethylacetamide have observed jaundice and liver injury, but can generally recover quickly. When someone uses this product as an anti-cancer drug and takes it orally in large doses, the symptoms caused by depression, sleepiness, and audio-visual hallucinations; heart, kidney and brain degeneration may also occur. DMA has toxic effects on mouse embryos and teratogenic effects on rabbits.

If this chemical is splashed into eyes, rinse it with running water for 15min immediately; If it comes into contact with skin, wash it immediately with a large amount of water. If swallowed, give medical attention, take it with a large amount of water to induce vomiting and lavage the stomach. For those who are unconscious, they will not induce vomiting and will be sent to the hospital for rescue. 

Workshop should be ventilated and production equipment should be airtight. When working in places with high vapor concentration, use organic vapor gas masks or air supply respirators, wear gloves and protective clothing to prevent absorption through the skin. Wear goggles to prevent splashing into your eyes. When working in places with splashes or spills, you should pay attention to the wet work clothes to be taken off immediately and the contaminated skin surface should be thoroughly cleaned. Give the workers clean work clothes before going to work every day and take a shower after work.

Special attention should be paid to the examination of skin, central nervous system, liver function or liver disease before employment and during regular physical examination.

Be packed in iron drums to prevent mechanical damage. Store in a cool, ventilated and dry place, avoid light exposure and stay away from any possible fire sources.

N,N-Dimethylacetamide is a toxic and flammable liquid, which must be stored and transported according to the regulations of toxic substances. When transporting, the container must be marked with "drugs" to prevent sun exposure and impact. When transporting, pay attention to handle with care.

Control incineration (incinerators must be equipped with scrubbers or thermal devices to reduce NOx emission).

Combustible in case of open flame, high temperature and strong oxidant; Combustion emits toxic nitrogen oxide smoke.

Foam, dry powder, carbon dioxide.

300 ppm.