Ruifu Chemical is the leading manufacturer of N,N-Diisopropylethylamine (DIPEA; Hunig's Base) (CAS: 7087-68-5) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase N,N-Diisopropylethylamine, Please contact: alvin@ruifuchem.com
| Chemical Name |
N,N-Diisopropylethylamine |
| Synonyms |
DIPEA; DIEA; N-Ethyldiisopropylamine; Hunig's Base; Huenig's Base; Hunig's Reagent; N-Ethyl-N,N-Diisopropylamine |
| Stock Status |
In Stock, Commercial Production |
| CAS Number |
7087-68-5 |
| Molecular Formula |
C8H19N |
| Molecular Weight |
129.25 g/mol |
| Melting Point |
-45℃ |
| Boiling Point |
127.0~128.0℃ |
| Flash Point |
12℃ |
| Density |
0.742 g/mL at 25℃(lit.) |
| Refractive Index n20/D |
1.41 |
| Sensitive |
Air Sensitive |
| Water Solubility |
Insoluble in Water |
| Solubility |
Soluble in Alcohol |
| COA & MSDS |
Available |
| Sample |
Available |
| Origin |
Shanghai, China |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
Colorless Transparent Liquid |
Colorless Transparent Liquid |
| Purity / Analysis Method |
>99.0% (GC) |
99.69% |
| Diisopropylamine |
<0.50% |
0.12% |
| Water by Karl Fischer |
<0.20% |
0.10% |
| Boiling Point |
127.0~128.0℃ |
127.2℃ |
| Refractive Index n20/D |
1.412~1.415 |
Complies |
| Density (20℃) |
0.742~0.760 g/ml |
Complies |
| Infrared Spectrum |
Consistent with Structure |
Complies |
| Conclusion |
The product has been tested and complies with the given specifications |
Package: Fluorinated Bottle, 25kg/Drum, 50kg/Drum, 200kg/Drum, or according to customer's requirement.
Storage: Keep the container tightly closed and store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Incompatible with acids, acid chlorides, acid anhydrides, carbon dioxide, copper, brass, rubber, oxidizing agents, nitrates, peroxides, aldehydes and metals.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Properties: This product should be colorless transparent liquid.
2. Content determination: according to gas chromatography (Chinese Pharmacopoeia 2010 edition Appendix VI E) determination.
Column type: SE-54 30m×0.25mm×0.5μm; FID detector;
Initial temperature: 80℃, initial 1 minute, heating rate 5℃/ minute, final temperature: 200℃, final time: 10 minutes
Temperature of detector: 230℃; Injection temperature: 200℃;
N2 flow rate: 20ml-30ml/min;
H2 flow rate: 20ml-30ml/min;
Air flow rate: 200ml-300ml/min;
Split ratio: 50:1;
Injection Volume: 0.2μl;
Amplifier sensitivity (RANGE) : 10*9.
Results: According to the area normalization method, the content should not be less than 99.0%, and the content of Diisopropylamine should not be more than 0.5%.
3. Water content determination: according to the moisture determination method (KF method) to determine, the water content of this product should be less than 0.2%.
4. Storage: Store in a cool and dry place away from light (2-8℃).
5. Reinspection period: one year
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes R11 - Highly Flammable
R22 - Harmful if swallowed
R34 - Causes burns
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R10 - Flammable
R41 - Risk of serious damage to eyes
R37/38 - Irritating to respiratory system and skin.
R20/22 - Harmful by inhalation and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
R61 - May cause harm to the unborn child
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
S16 - Keep away from sources of ignition.
S27 - Take off immediately all contaminated clothing.
S60 - This material and its container must be disposed of as hazardous waste.
S23 - Do not breathe vapour.
S9 - Keep container in a well-ventilated place.
S53 - Avoid exposure - obtain special instructions before use.
UN IDs UN 2734 8/PG 2
WGK Germany 2
FLUKA BRAND F CODES 9-34
TSCA Yes
HS Code 2942000000
Hazard Note Highly Flammable/Corrosive/Harmful
Hazard Class 3
Packing Group II
Toxicity LD50 orally in Rabbit: > 200 - 500 mg/kg
N,N-Diisopropylethylamine (CAS: 7087-68-5) is also known as Hunig's base and abbreviated as DIPEA or DIEA, It is a sterically hindered amine and an organic compound. The colourless liquid was named as Hung’s base after Siegfried Hunig, a German chemist. In organic chemistry, N,N-Diisopropylethylamine is used as a base. Since the nitrogen centre is isolated by an ethyl group and the two isopropyl groups, It can bind to protons. The compound is, therefore, a base similar to 2,2,6,6-tetramethylpiperidine, but a poor nucleophile, a blend of properties that makes it valuable as an organic reagent.
N,N-Diisopropylethylamine (DIPEA; Hunig's Base) (CAS: 7087-68-5) exhibits violent reaction as well as flammability with nitrates, oxidizing agents, and peroxides. It can also react very exothermically and possibility of spitting with halogens and strong acids. In an alkaline environment, the compound is likely to react violently. In addition, the compound can form toxic products such as n-nitrosamines when combined with nitrous acid as well as oxygen, nitrosating agents, and nitrates. Under normal conditions (temperature and pressure), DIPEA is very stable. However, it is soluble in most organic solvents.
N,N-Diisopropylethylamine (DIPEA; Hunig's Base) (CAS: 7087-68-5) is utilized as a base in the palladium(0) catalysed alkoxycarbonylation of both allyl acetates and phosphates. It is used as a neutralizer of the produced phosphoric acid. Notably, the alkyl ester cannot be produced without DIPEA. When combined with boryl triflates, N,N-Diisopropylethylamine is used in the enolate synthesis of ketones for application in directed cross-adol reactions. DIPEA is applied as a proton scavenger in organic synthesis. Since the compound is a sterically hindered amine, it lacks quaternization; therefore, making it a perfect choice of a base for use with extremely reactive alkylating agents. DIPEA is specifically useful as a base in the protection of alcohols as substituted ethers in the field of protecting group chemistry. In the synthesis of peptides, the compound is also used in the coupling of amino acids. The steric nature and basicity of DIPEA during the coupling reaction affects the degree of racemization.
N,N-Diisopropylethylamine is an important pesticide and pharmaceutical intermediate, which can be used to synthesize anesthetics and herbicides, and can also be used as a sterically hindered amine to participate in various catalytic reactions. Biochemical research. Important organic synthesis intermediates, mainly used in medicine, pesticide intermediate synthesis, can also be used as solvent, condensation agent, catalyst, for amino acid peptide synthesis, etc.
