Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N-Fluorobenzenesulfonimide (NFSI) (CAS: 133745-75-2) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase N-Fluorobenzenesulfonimide, Please contact: alvin@ruifuchem.com
| Chemical Name |
N-Fluorobenzenesulfonimide |
| Synonyms |
NFSI; Accufluor NFSi; NFBS; N-Fluorobis(phenylsulfonyl)amine; N-Fluorodi(benzenesulfonyl)amine; N-Fluorodibenzenesulfonimide |
| Stock Status |
In Stock, Commercial Scale |
| CAS Number |
133745-75-2 |
| Molecular Formula |
C12H10FNO4S2 |
| Molecular Weight |
315.33 g/mol |
| Melting Point |
114.0 to 119.0℃ |
| Solubility |
Very Soluble in Acetonitrile, Dichloromethane or THF |
| Storage Temp. |
Cool & Dry Place (2~8℃) |
| COA & MSDS |
Available |
| Category |
Fluorinating Reagent |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White to Off-White Crystal |
White Crystal |
| Melting Point |
114.0 to 119.0℃ |
115.7~118.0℃ |
| Loss on Drying |
<0.50% |
0.03% |
| Residue on Ignition |
<0.20% |
0.05% |
| Purity / Analysis Method |
>98.0% (HPLC) |
98.87% |
| Infrared Spectrum |
Conforms to Structure |
Complies |
| 1 H NMR Spectrum |
Conforms to Structure |
Complies |
| Conclusion |
The product has been tested & complies with the given specifications |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture. Incompatible with oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany 3
FLUKA BRAND F CODES 10
TSCA No
Hazard Note Oxidising Agent
Hazard Class IRRITANT
N-Fluorobenzenesulfonimide (NFSI) (CAS: 133745-75-2), Versatile fluorinating reagent used in the fluorination of aryls, enolates, carbanions, organolithiums, etc.
N-Fluorobenzenesulfonimide is a commonly used electrophilic fluorinating agent in organic synthesis to introduce fluorine into neutral organic molecules. It is also used to fluorinate nucleophilic substrates such as reactive organometallic species and malonate anions. NFSi can be synthesized by the reaction of benzenesulfonimide with fluorine.
N-Fluorobenzenesulfonimide is a new, stable and mild fluorination reagent, which can introduce fluo rine atoms into the carbonyl ortho position of organic molecules, and can perform monofluorination reaction on electron-rich aromatic compounds, enol sila ne, ene Chemicalbook alcohol lithium salt, etc. The current research hotspots include Nazarov cyclization reaction catalyzed by iron or cobalt to form five-membered ring, and asymmetric catalysis of enantioselective α-fluorination.
N-Fluorobenzenesulfonimide fluorinates aromatics, enolates, azaenolates and carbanions in high yield. It is used for diastereoselective fluorination of Li enolates of chiral carboximides, for directed fluorination of ortho-lithiated aromatics and for a review of electrophilic N-F fluorinating agents. Asymmteric fluorinations is effected in the presence of a Pd-BINAP catalyst system at room temperature in an ionic liquid. It is a reagent employed in a palladium-catalyzed enantioselective fluorination of t-butoxycarbonyl lactones and lactams. It is also used in the electrophilic difluorination of dihalopyridines with butyl lithium and in the direct conversion of alcohols to dibenzenesulfonamides with triphenylphosphine.