Shanghai Ruifu Chemical is the leading manufacturer and supplier in glycoscience field, can supply N-Methyl-D-Glucamine (Meglumine) (CAS: 6284-40-8) with high quality, large scale production. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase N-Methyl-D-Glucamine (Meglumine), Please contact: alvin@ruifuchem.com
| Chemical Name | N-Methyl-D-Glucamine |
| Synonyms | Meglumine; 1-Deoxy-1-(Methylamino)-D-Glucitol; N-Methylglucamine; D(-)-N-Methylglucamine; 1-Deoxy-1-Methylaminosorbitol |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 6284-40-8 |
| Molecular Formula | C7H17NO5 |
| Molecular Weight | 195.22 g/mol |
| Melting Point | 128.0~132.0℃ |
| Sensitive | Air Sensitive. Hygroscopic. Store Under Argon. Ambient Temperatures. |
| Water Solubility | Soluble in Water, Almost Transparency |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Shelf Life | 24 Months in the Original Package When Properly Stored |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White Crystalline Powder | Conforms |
| Meglumine Assay | 99.0%~100.5% (Titration) | 99.6% |
| Specific Rotation [a]20/D | -15.7° ~ -17.3° (100 mg/mL, Undried, in Water) | -16.03° |
| Melting Point | 128.0~132.0℃ | 128.4~130.1℃ |
| Loss on Drying | <0.50% | 0.24% |
| Residue on Ignition | <0.10% | 0.03% |
| Heavy Metals (Pb) | <20ppm | <10ppm |
| Absence of Reducing Substances | Blue Don't Change to Red | Conforms |
| Ultraviolet Absorbancy Degree | ≤0.03 (200 mg/ml, H2O, 420nm) | 0.01 |
| Clarity of the Solution | Clear and Colourless Solution | Conforms |
| Readily Carbonizable Substance | No Deeper than the Orange Red no. 2 | Conforms |
| Infrared Spectrum | Consistent with Structure | Conforms |
| Conclusion | The product has been tested and complies with the USP40 Standard | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Air sensitive and hygroscopic. Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Incompatible with strong oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Meglumine
C7H17NO5 195.21
D-Glucitol, 1-deoxy-1-(methylamino)-;
1-Deoxy-1-(methylamino)-D-glucitol [6284-40-8]
DEFINITION
Meglumine contains NLT 99.0% and NMT 100.5% of meglumine (C7H17NO5), calculated on the dried basis.
IDENTIFICATION
• A.
Sample solution: Transfer 250 mg to a dry, 50-mL centrifuge tube, add 500 mg of sodium metaperiodate, then add 5 mL of water rapidly in one portion. Allow to stand undisturbed.
Analysis: The solution instantly turns yellow, and heat is produced. The color then changes from deep yellow to orange-brown (rust), and after 20 min, the rust-colored solution is cloudy. Then add 2 mL of 2.5 N sodium hydroxide.
Acceptance criteria: The mixture turns bright yellow and becomes clear.
ASSAY
• PROCEDURE
Sample: 500 mg
Titrimetric system
Mode: Direct titration
Titrant: 0.1 N hydrochloric acid
Endpoint detection: Visual
Analysis: Transfer the Sample into a conical flask, dissolve in 40 mL of water, and add 2 drops of methyl red TS. Titrate with Titrant. Each mL of Titrant is equivalent to 19.52 mg of meglumine (C7H17NO5).
Acceptance criteria: 99.0%-100.5% on the dried basis
IMPURITIES
Delete the following:
• HEAVY METALS <231>
Test preparation: Dissolve 1 g in 20 mL of water, add phenolphthalein TS, neutralize with 3 N hydrochloric acid, and dilute with water to 25 mL.
Acceptance criteria: NMT 20 µg/g• (Official 1-Dec-2015)
• RESIDUE ON IGNITION <281>: NMT 0.1%
SPECIFIC TESTS
ABSENCE OF REDUCING SUBSTANCES
Sample solution: 50 mg/mL
Analysis: To 5 mL of Sample solution add 5 mL of alkaline cupric tartrate TS, and heat to boiling.
Acceptance criteria: The color of the solution does not change.
• COMPLETENESS AND COLOR OF SOLUTION
Sample solution: 200 mg/mL
Instrumental conditions
(See Spectrophotometry and Light-Scattering <851>.)
Mode: Vis
Analytical wavelength: 420 nm
Cell: 1 cm
Blank: Water
Analysis
Sample: Sample solution
Acceptance criteria: Adsorbance is NMT 0.030.
LOSS ON DRYING <731>
Sample: 1 g
Analysis: Dry the Sample at 105℃ to constant weight.
Acceptance criteria: NMT 1.0%
• MELTING RANGE OR TEMPERATURE <741>: 128℃-132℃
• OPTICAL ROTATION, Specific Rotation <781S>
Sample solution: 100 mg/mL, undried, in water
Acceptance criteria: -15.7° to -17.3°
ADDITIONAL REQUIREMENTS
• PACKAGING AND STORAGE: Preserve in well-closed containers.
N-Methyl-D-Glucamine (Meglumine) (CAS: 6284-40-8) Synthetic Route
Raw Materials: Glucose, Ethanol, Methylamine, Catalyst Ni, H2
Condensation Hydrogenation
Filter
Cooling Crystallization
Filter
Meglumine Crude
Meglumine Powder
Packing and Storage
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LZ4295770 |
| FLUKA BRAND F CODES | 3-10-23 |
| TSCA | Yes |
| HS Code | 2922199090 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
N-Methyl-D-Glucamine (Meglumine) (CAS: 6284-40-8) is used as an intermediate of Meglumine Diatrizoate, Flunixin Meglumine, Methylglucamine Antimonate
Meglumine is used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. Meglumine is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.
Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
Meglumine is often used as an excipient in pharmaceuticals and in conjunction with iodinated compounds in contrast media such as diatrizoate meglumine and iodipamide meglumine.
The co-solvents as a contrast agent and a surfactant. Diagnostic medicine, as a co-solvent and a contrast agent. Diagnostic agents, solubilizers contrast agent, surfactant. Biochemical studies.
Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.