Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Ketorolac Tromethamine Salt (CAS: 74103-07-4) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com
| Chemical Name |
Ketorolac Tromethamine Salt |
| Synonyms |
Ketorolac Tris Salt; Ketorolac (Tromethamine Salt); Ketorolac Tromethamine; rac Ketorolac Tromethamine Salt; Toradol; (±)-5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid Tris Salt; (±)-Form Tromethamine Salt |
| CAS Number |
74103-07-4 |
| Stock Status |
In Stock, Commercially Manufactured |
| Molecular Formula |
C15H13NO3·C4H11NO3 |
| Molecular Weight |
376.41 |
| Melting Point |
160.0~161.0℃ |
| Boiling Point |
493.2℃ at 760 mmHg |
| Sensitive |
Hygroscopic. Light Sensitive |
| λmax |
322nm(MeOH)(lit.) |
| COA & MSDS |
Available |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White to Off-White Crystalline Powder |
| Identification |
IR: Concordant with the Spectrum Obtained with Ketorolac Tromethamine CRS |
| TLC: Color and Position of Principal Spot Obtained with Test Solution Consistent with that of the Reference Solution |
| pH |
5.7~6.7 |
| Melting Point |
160.0~161.0℃ |
| Purity / Analysis Method |
>99.0% (HPLC) |
| Assay / Analysis Method |
98.5~101.5% (on the Dried Basis) |
| Loss on Drying |
<0.50% |
| Residue on Ignition |
<0.10% |
| Heavy Metals (Pb) |
≤20ppm |
| Related Substances |
|
| Impurity RRT0.54 |
<0.50% |
| Impurity RRT0.66 |
<0.50% |
| Ketorolac 1-Keto Analog |
<0.10% |
| Ketorolac 1-Hydroxyl Analog |
<0.10% |
| Any Other Single Impurity |
<0.20% |
| Total Impurities |
<1.00% |
| Residual Solvents |
|
| Dichloroethane |
<50ppm |
| Anhydrous Ethanol |
<5000ppm |
| Microorganism Limits |
|
| Bacteria Amount |
<1000cfu/g |
| Mould and Yeast Amount |
<100cfu/g |
| Escherichia. Coli |
Absent |
| Bacterial Endotoxin |
<5EU/mg |
| Infrared Spectrum |
Conforms to Structure |
| Solubility in H2O |
Colorless to Faint Yellow Clear (15 mg/ml) Pass |
| Test Standard |
Enterprise Standard |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Ketorolac Tromethamine Salt (CAS: 74103-07-4) is a nonsteroidal antiinflammatory agent that exhibits analgesic and antipyretic activity. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2. Ketorolac Tromethamine Salt is effective in the management of moderate to severe postoperative pain. It is, however, the first of this type of agent to be administered parenterally as an analgesic and is specifically indicated for intramuscular injection. Ketorolac represents a useful alternative to the narcotic analgesics due to its lack of abuse potential. It is used primarily for its analgesic effects for short-term treatment of mild to moderate pain in dogs and rodents. The duration of analgesic effect in dogs is about 8-12 hours, but because of the availability of approved, safer NSAIDs for dogs, its use is questionable. An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Hazard Symbols T - Toxic
Risk Codes
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin.
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
RTECS UY7759900
HS Code 2933995500
Hazard Class 6.1(a)
Packing Group II