Commercial Supply Imatinib Mesylate and Related Intermediates:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Chemical Name | Imatinib Mesylate (alpha form) |
| Synonyms | Imatinib Methanesulfonate; STI571 Mesylate; CGP-57148B |
| CAS Number | 220127-57-1 |
| CAT Number | RF-API19 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C30H35N7O4S |
| Molecular Weight | 589.71 |
| Shipping Condition | Under Ambient Temperature |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystalline Powder |
| Solubility | Easy to dissolve in the water |
| HPLC Identification | Sample spectrum main peak retention time conforms with that |
| IR Identification | Infrared absorption spectrum of sample conforms with reference sample |
| Melting Point | 214.0~222.0℃ |
| Loss on Drying | ≤0.50% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals | ≤20ppm |
| Related Substances | (1) Impurity G: NMT 0.3% |
| (2) Impurity B: NMT 0.3% | |
| (3) Impurity C: NMT 0.3% | |
| (4) Impurity D: NMT 0.3% | |
| (5) Impurity A: NMT 0.3% | |
| (6) Impurity H: NMT 0.3% | |
| (7) Impurity F: NMT 0.3% | |
| (8) Impurity E: NMT 0.3% | |
| (9) The biggest single impurity: NMT0.1% | |
| Residual Solvents | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| HPLC Assay | 98.0%~102.0% (C30H35N7SO4 Calculated on the Anhydrous Basis) |
| Test Standard | Enterprise Standard |
| Usage | API; Ph+CML |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Imatinib Mesylate(CAS 220127-57-1) is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It's a potent and selective v-Abl tyrosine kinase inhibitor (IC50 = 38 nM). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib mesylate binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit.