Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Homotaurine (CAS: 3687-18-1) with high quality, commercial production. To buy Homotaurine, please contact: alvin@ruifuchem.com
| Chemical Name |
Homotaurine |
| Synonyms |
Tramiprosate; 3-Amino-1-Propanesulfonic Acid; 3-Aminopropane-1-Sulfonic Acid; 3-APS |
| CAS Number |
3687-18-1 |
| CAT Number |
RF-PI1676 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C3H9NO3S |
| Molecular Weight |
139.17 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White Needle Crystal or Crystalline Powder |
| Odor |
Odorless and Subacid |
| Solubility |
Soluble in Water; Slightly Soluble in Ethanol |
| Purity / Analysis Method |
>99.5% (Titration) |
| Melting Point |
285.0~295.0℃ |
| Loss on Drying |
<0.20% |
| Residue on Ignition |
<0.10% |
| Clarity of Solution |
Colorless and Clear (50 mg/ml, H2O) |
| Heavy Metals (as Pb) |
<0.001% |
| Arsenic (as As) |
<0.0002% |
| Chloride (as Cl) |
<0.01% |
| Sulphate (as SO4) |
<0.01% |
| Ammonium Salt (as NH4) |
<0.02% |
| Readily Carbonizable Substance |
Colorless Solution |
| Infrared Spectrum |
Infrared Spectrum |
| NMR |
Consistent With Structure |
| Test Standard |
Enterprise Standard |
| Usage |
API; Pharmaceutical Intermediates; GABA Antagonist |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
Homotaurine (CAS: 3687-18-1), also known as Tramiprosate, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. Homotaurine is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.