Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Histrelin Acetate (CAS: 76712-82-8) with high quality. Ruifu Chemical supplys a series of GMP peptides. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Histrelin Acetate, Please contact: alvin@ruifuchem.com
| Chemical Name |
Histrelin Acetate |
| Synonyms |
Histrelin; Histrelin Acetic Acid Salt; Brand name Supprelin (Roberts Pharmaceutical); [des-Gly 10, D-His(Bzl) 6]-LH-RH Ethylamide; 5-oxo-L-Prolyl-L-Histidyl-L-Tryptophyl-Lseryl- L-Tyrosyl-Nt-Benzyl-D-Histidyl-L-Leucyl-L-Arginyl-N-Ethyl-L-Prolinamide Diacetate |
| Peptide Sequence |
Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt Acetate Salt |
| Salt Form |
Acetate |
| Stock Status |
In Stock, Commercial Scale |
| CAS Number |
76712-82-8 |
| Molecular Formula |
C66H86N18O12 |
| Molecular Weight |
1323.52 g/mol |
| Density |
1.46±0.10 g/cm3 |
| Sensitive |
Hygroscopic. Moisture Sensitive |
| Storage Temp. |
Cool & Dry Place (2~8℃). Refrigerator |
| COA & MSDS |
Available |
| Category |
GMP Peptides |
| Shelf Life |
24 Months From Manufacture Date if Stored Properly |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White Lyophilized Powder |
Conforms |
| Solubility |
Soluble in Water or 1% Acetic Acid at a Concentration of ≥1mg/ml to Give a Clear Colorless Solution |
Conforms |
| MS |
Monoisotopic Mass: 1323±1.0 |
1323.1 |
| Identity HPLC |
Same with the Reference Solution |
Conforms |
| Amino Acid Analysis |
Ser: Present |
Conforms |
| Glu: 0.85~1.1 |
0.95 |
| Pro: 0.85~1.1 |
1.05 |
| Leu: 0.85~1.1 |
1.01 |
| Tyr: 0.85~1.1 |
1.00 |
| His: 1.70~2.2 |
0.99 |
| Arg: 0.85~1.1 |
0.98 |
| Trp: Present |
Determined |
| Peptide Purity (HPLC) |
≥98.0% |
99.58% |
| Related Substances (HPLC) |
Total Impurities(%) ≤2.0% |
0.42% |
| Any Other Impurity ≤1.0% |
0.24% |
| Acetate Content (HPLC) |
≤12.0% |
11.5% |
| Water Content (Karl Fischer) |
≤5.0% |
1.0% |
| Assay |
95.0~105.0% (Anhydrous, Acetic Acid Free) |
98.5% |
| Origin of Product |
Synthetic |
|
| Attention |
Only for Research, Not for Human Use |
|
| Conclusion |
The product has been tested & complies with the specifications |
Package: Plastic vial (dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols T - Toxic
Risk Codes
60 - May impair fertility
Safety Description
S53 - Avoid exposure - obtain special instructions before use.
S22 - Do not breathe dust.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany 3
RTECS OK6370800
Histrelin Acetate (CAS: 76712-82-8), a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.
Definition: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. Used for precocious puberty.
Biochem/Physiol Actions: Histrelin Acetate is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs.
It is available as a daily intramuscular injection. Histrelin is also available in a 12-month subcutaneous implant (Vantas) for the palliative treatment of advanced prostate cancer (since 2005 in the US, and since Jan 2010 in the UK. A 12-month subcutaneous implant (Supprelin LA) for central precocious puberty (CPP) was approved on May 3, 2007 by the U.S. Food and Drug Administration.