Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Fmoc-Glycine (Fmoc-Gly-OH) (CAS: 29022-11-5) with high quality. Ruifu Chemical supplys a series of amino acids. We provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Fmoc-Glycine, Please contact: alvin@ruifuchem.com
| Chemical Name | Fmoc-Glycine |
| Synonyms | Fmoc-Gly-OH; N-Fmoc-Glycine; Fmoc-L-Glycine; Fmoc-L-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine; N-(9-Fluorenylmethoxycarbonyl)-Glycine |
| Stock Status | In Stock, Production Capacity 20 Tons per Month |
| CAS Number | 29022-11-5 |
| Molecular Formula | C17H15NO4 |
| Molecular Weight | 297.31 g/mol |
| Melting Point | 165.0~185.0℃ |
| Density | 1.316 |
| Solubility in Methanol | Almost Transparency |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Fmoc-Amino Acids |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Appearance | White Powder | White Powder |
| Purity / Analysis Method | >99.0% (HPLC) | 99.85% |
| Melting Point | 165.0~185.0℃ | 177.0~177.1℃ |
| Water by Karl Fischer | <0.50% | 0.26% |
| Clarity of Solution | 0.3 gram in 2ml DMF Clear Solution | Complies |
| Fmoc-β-Ala-OH | <0.10% (HPLC) | Complies |
| Fmoc-β-Ala-Gly-OH | <0.10% (HPLC) | Complies |
| Fmoc-Gly-Gly-OH | <0.10% (HPLC) | Complies |
| Fmoc-Val-OH | <0.10% (HPLC) | Complies |
| Fmoc-Ala-OH | <0.10% (HPLC) | Complies |
| Fmoc-Leu-OH | <0.10% (HPLC) | Complies |
| Fmoc-lle-OH | <0.10% (HPLC) | Complies |
| Each Unspecified Impurity | <0.20% (HPLC) | Complies |
| Assay Free Amino Acid | <0.20% (GC) | Complies |
| Ethyl Acetate | <0.50% (GC) | Complies |
| Mass Spectrum | In Accordance With the Standard | Complies |
| NMR Spectrum | In Accordance With the Standard | Complies |
| Conclusion | The product has been tested & complies with the given specifications | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
HS Code 2922491990
Fmoc-Glycine (Fmoc-Gly-OH) (CAS: 29022-11-5) is an N-Fmoc-protected form of Glycine. Glycine is a nonessential amino acid. Fmoc-amino acids, used in peptide synthesis, used as an organic synthesis intermediate, pharmaceutical intermediate, biochemical reagent or chemical reagent.
Introduction: Fmoc-Glycine is Glycine protected by Fmoc. Fluorene methoxycarbonyl (Fmoc) is a base-sensitive protective group, which can be used in concentrated ammonia water or dioxane-methanol-4N NaOH(30:9:1) and piperidine, ethanolamine, cyclohexylamine, 1,4-Dioxane, pyrrolidone and other ammonia 50% dichloromethane solution. Under weak alkaline conditions such as sodium carbonate or sodium bicarbonate, Fmoc protecting group is generally introduced by Fmoc-Cl or Fmoc-OSu.
Application: Fmoc-Glycine is Fmoc-protected Glycine, which is mainly used to synthesize polypeptides. The difference of amino acid protection groups has a great impact on the efficiency and yield of polypeptide synthesis. For example, Fmoc-Glycine can be used to prepare a glycine derivative corrosion inhibitor, and the Fmoc-protecting group and hydrophobic long chain are connected to the Glycine molecule through the amidation reaction, and the heteroatom (N, O, etc.) Or unsaturated bonds) and the bisphenyl ring containing π electrons are adsorbed on the metal, and the hydrophobic long chain blocks the water molecules, so that it forms a protective film on the steel surface to achieve the purpose of corrosion protection.
Preparation: Fmoc-Glycine synthesis specific steps are as follows: 3.0g Glycine is dissolved in 115ml of 10% Na2CO3, cooled to -4~0℃,11.2g Fmoc-Cl dissolved in 35.0ml of acetone and added to the system dropwise, after dropwise addition, stirring in ice bath for 30min, and then stirring at room temperature for 2.0h. The reaction progress was monitored by thin layer chromatography. After the reaction was completed, 400ml of water was poured into water, ether was extracted twice, cooled and adjusted to pH2 with concentrated hydrochloric acid, a large amount of white solid was precipitated, 50 ml of ethyl acetate was extracted three times, anhydrous magnesium sulfate was dried, solvent was distilled under reduced pressure, and petroleum ether was used to precipitate to obtain 11.5g of Fmoc-Glycine. After purification, the purity of the product was 97.35% by high performance liquid chromatography.