Manufacturer Supply High Quality, Commercial Production
Chemical Name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
CAS: 160129-45-3
| Chemical Name |
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one |
| Synonyms |
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one; 7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one |
| CAS Number |
160129-45-3 |
| CAT Number |
RF-PI395 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C10H10ClNO |
| Molecular Weight |
195.65 |
| Melting Point |
103.0 to 107.0℃ |
| Solubility |
Soluble in Methanol |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
Light Green to Light Yellow Powder |
| Identification Methods |
NMR, HPLC |
| Purity / Analysis Method |
≥99.0% (HPLC) |
| Loss on Drying |
≤1.0% |
| Residue on Ignition |
≤0.50% |
| Any Single Impurity |
≤0.50% |
| Total Impurities |
≤1.0% |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Tolvaptan (CAS 150683-30-0), treatment of Hyponatremia |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) is an intermediate in the synthesis of Tolvaptan (CAS 150683-30-0). Tolvaptan is a selective, competitive orally active nonpeptide arginine vasopressin V2 receptor antagonist with an IC50 of 1.28µM for the inhibition of AVP-induced platelet aggregation. Tolvaptan is used to treat hyponatremia associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone. Tolvaptan is also in fast-track clinical trials for polycystic kidney disease. Treatment with Tolvaptan causes rapid and sustained body weight reductions concurrent with increases in urine output, improves and/or normalizes serum sodium in hyponatremic patients, reduces signs and symptoms of congestion and increases thirst.