| Chemical Name |
(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| Synonyms |
Ezetimibe Intermediate ZT-5 |
| CAS Number |
189028-95-3 |
| CAT Number |
RF-PI146 |
| Stock Status |
In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula |
C20H20FNO4 |
| Molecular Weight |
357.38 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White or Off-White Powder |
| Purity / Analysis Method |
≥98.0% (HPLC) |
| Impurity ZT-4 |
≤1.0% |
| Enantiomer |
≤0.20% |
| Single Impurity |
≤1.5% |
| Total Impurities |
≤2.0% |
| Test Standard |
Enterprise Standard |
| Usage |
Ezetimibe (CAS: 163222-33-1) Intermediate |
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one (CAS: 189028-95-3) with high quality. It is an intermediate typically in the synthesis of Ezetimibe (CAS: 163222-33-1)
Ezetimibe (CAS: 163222-33-1) is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.It takes effect throughacting at the brush border of the small intestine and inhibiting the absorption of cholesterol, further leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of blood cholesterol.