| Chemical Name | Ethyl (S)-4-Chloro-3-hydroxybutyrate |
| Synonyms | (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester |
| CAS Number | 86728-85-0 |
| CAT Number | RF-PI139 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C6H11ClO3 |
| Molecular Weight | 166.6 |
| Boiling Point | 93-95℃ 5 mm Hg (lit.) |
| Density | 1.19 g/mL at 25℃ (lit.) |
| Refractive Index | n20/D 1.453 (lit.) |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Colorless to Pale Yellow Liquid |
| Purity / Analysis Method | ≥98.0% (GC) |
| Moisture (K.F) | ≤0.50% |
| Ethyl-4-Chloro Aceto Acetate | ≤0.50% |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediate; Organic Synthesis |
Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0)
Method of analysis
Description
Take about 10ml sample in a clean and dry glass plate and check.
Specific rotation
Transfer accurately about 1.0g of sample to 100ml volumetric flask and dissolved in 10 ml of chloroform, then dilute with chloroform to 100ml and mix.
Measure the optical rotation of the test sample at 25ºC and 589nm wavelength calculate the specific rotation as per the given formula.
[α]25D = (v×a)/[w×(1-b)]
[α]25D: the specific rotation of test sample; α: the observed rotation in angular degree; w: sample weight (g);
v: volume (mL);
b: Water content(%)
Purity (by GC)
Chromatographic conditions: The Gas chromatography is equipped with flame ionization detector
Column: SE-54, 30m×0.35mm×0.25µm
Oven temperature: Initial temp 120℃, Hold time for 2min
Ramp: 20℃/min
Temp: 250℃, Hold time for 2min
Injector temperature: 250℃
Detector temperature: 250℃(FID)
Injection volume: 0.2µl
Sample solution: dilute 1ml A4 with 1ml acetone.
Procedure: Inject 0.2µl of the acetone as blank and record the chromatogram. In the chromatogram obtained from diluent there should not be any interference at the retention time of the main peak and impurity peak. Than Inject the sample solution in duplicate into the chromatograph and record the chromatogram. Report the Purity of sample by area normalization method.
Package: Bottle, Barrel, 25kg/Barrel, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0) with high quality, it is an intermediate typically in the synthesis of Atorvastatin Calcium (CAS: 134523-03-8).
Atorvastatin Calcium (CAS: 134523-03-8) [trade name: Lipitor] is mainly indicated for the treatment of cardiovascular disease and dyslipidemia due to its effect in lowering the cholesterol in the blood. Being similar to other kinds of statins, atorvastatin take effects by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels further increases hepatic uptake of cholesterol and reduces plasma cholesterol levels . Lipitor, since 1996, has become the world's best-selling medication to that point.