Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of (-)-Epigallocatechin Gallate Hydrate (EGCG Hydrate) (CAS: 989-51-5) with high quality, green tea extract. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase (-)-Epigallocatechin Gallate Hydrate, Please contact: alvin@ruifuchem.com
| Chemical Name | (-)-Epigallocatechin Gallate Hydrate |
| Synonyms | EGCG Hydrate; Green Tea Extract EGCG; Epigallocatechin 3-Gallate; 3-O-Galloylepigallocatechin; Teatannin II; (-)-cis-3,4-Dihydro-5,7-Dihydroxy-2-(3,4,5-Trihydroxyphenyl)-1(2H)-Benzopyran-3-yl Gallate Hydrate; (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-Dihydro-1(2H)-Benzopyran-3,5,7-triol 3-Gallate, (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-Flavane-3-Gallate |
| Botanical Source | Green Tea Leaves |
| Stock Status | In Stock, Commercially Manufactured |
| CAS Number | 989-51-5 |
| Molecular Formula | C22H18O11·xH2O |
| Molecular Weight | 458.38 (as Anhydrous) |
| Melting Point | 212℃ |
| Density | 1.90±0.10 g/cm3 |
| Specific Rotation [a]20/D | -165.0° to -186.0° (C=1 in EtOH) |
| Sensitive | Air Sensitive, Light Sensitive, Moisture Sensitive |
| Solubility | Practically Soluble in Water and Ethanol |
| COA & MSDS | Available |
| Category | Natural Plant Extract |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Characters/Appearance | Light Yellow Powder | Complies |
| Analysis Method | HPLC-DAD or/and HPLC-ELSD | Complies |
| Identification Methods | Mass, NMR | Complies |
| Assay / Analysis Method | >99.0% (by HPLC) | 99.26% |
| Odor and Taste | Bitter | Bitter |
| Mesh Size/Sieve | 80 Mesh | Complies |
| Solubility | Practically Soluble in Water and Ethanol | Complies |
| Residual Solvent | Ethanol: <0.50% | 0.25% |
| Loss on Drying | <3.00% | 0.66% |
| Sulphated Ash | <0.20% | 0.14% |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Pesticides | <1.3ppm | Negative |
| Aflatoxins | ||
| B1 | ≤5ppb | Negative |
| -Sum of B1+B2+G1+G2 | ≤10ppb | Negative |
| Microbiological Tests | Ph. Eur. category 3A | |
| Total Plate Count | <100cfu/g | 65cfu/g |
| Yeast & Mold | <100cfu/g | 9cfu/g |
| Escherichia Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Solubility in H2O (5 mg/ml) | Colorless to Faint Yellow, Faint Red, Clear | Pass |
| Storage Temp. | Store in Tight, Light-resistant Containers, Avoid Exposure to Direct Sunlight, Moisture and Excessive Heat | |
| Shelf Life | 2 Years if Stored Properly, Sealed and Avoid direct Sun Light | |
| Conclusion | Has been tested & complies with the European Pharmacopoeia 4 | |
Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Package: Brown vial or HDPE plastic bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat. Store in a cool, dry and well-ventilated warehouse away from incompatible substances.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Safety Description 24/25 - Avoid contact with skin and eyes.
WGK Germany 2
RTECS KB5200000
FLUKA BRAND F CODES 10-23
HS Code 2942000000
Toxicity LD50 oral in mouse: 2170mg/kg
(-)-Epigallocatechin Gallate Hydrate (EGCG Hydrate) (CAS: 989-51-5), green tea extract, is a strong polyphenol catechin antioxidant found in green tea, is a potent polyphenolic flavonoid which is found as a component of tea. It exhibits antioxidant, antimutagenic, antitumor and anti-inflammatory properties, thereby contributing to the health-beneficial actions. It finds potential use as a drug candidate in the pharmaceutical, cosmetic, and nutritional fields.
(-)-Epigallocatechin Gallate, the major catechin accounting for 59% of the total catechins in green tea, is a powerful antioxidant as well as an antiangiogenic and antitumor agent. EGCG has been studied for its role in the chemoprevention of a wild range of cancers, including liver, stomach, skin, lung, mammary gland and colon cancers. study results show that egcg is able to induce apoptosis, promote cell growth arrest and block carcinogenesis by affecting signal transduction pathways.
Function:
1) EGCG can reduce blood pressure, blood sugar, blood lipids.
2) EGCG has the function of removing radicals and anti-aging.
3) EGCG can enhance the immune function and prevention of colds.
4) EGCG has the function of anti-radiation, anti-cancer, inhibiting the increasing of cancer cell. With strong anti-xxidation activity,it can eliminate body's free radical and resist tumor mutation,aging,inflammatory,virus etc
5) EGCG is used to anti-bacterium, with the function of sterilization and deodorization.
6) Enhancing metabolism and fat oxidation.
7) EGCG is widely used in field of foodstuff,medication and daily use chemical products.
8) EGCG also can prevent and treat malignant tumor,hyperlipemia,arteriosclerosis,cerebral thrombosis, diabetes an obisity etc.
Application:
1) Applied in food field, EGCG is used as natural antioxidant, antistaling agent, and anti-fading agents. Adds tea polyphenols in foods can maintain original flavor, preventing corruption and discoloration, with the function of restraining and killing bacteria, which will improve the food hygiene standards.
2) Applied in pharmaceutical field, it is also used to treat cardiovascular disease, diabetes and cancer.
3) Applied in cosmetic field, EGCG owns the effect of anti-wrinkle and anti-Aging. Protecting skin from the harmful sun exposure, which will prevent skin cancer.
The extraction methods of tea polyphenols from tea mainly include precipitation separation method, adsorption separation method, organic solvent extraction method, low temperature purification enzyme extraction method, salting-out method, the new developed methods include supercritical solvent extraction. Here we introduce the most commonly used calcium salt precipitation separation method. After crushing, the tea leaves are soaked in hot water at 80℃ for 30min in the extraction kettle, filtered, the filter cake is washed with a small amount of boiling water, the washing solution is combined with the filtrate, and other components such as caffeine can be extracted after the filter cake is dried. The filtrate is poured into the precipitation vessel, and saturated lime water, saturated lime water and saturated salt water are added at a ratio of about 1:6:5 of filtrate: lime water: salt water. After fully stirring, the mixture is allowed to stand for 30 min, filtration. The filter cake was then placed in an acidifier and 0.5%~0.8% of the H2S04, adjust the pH of a 7.1~7.2, and then use acetic acid or citric acid to adjust the pH value to 7.0, fully stirred, then stand for 30min, filter, wash, the filtrate was spray-dried to obtain the finished product.