Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of D-Serine (H-D-Ser-OH) (CAS: 312-84-5) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase D-Serine, Please contact: alvin@ruifuchem.com
| Chemical Name |
D-Serine |
| Synonyms |
H-D-Ser-OH; Dextro-Serine; (R)-Serine; D-2-Amino-3-Hydroxypropionic Acid; (R)-2-Amino-3-Hydroxypropanoic Acid; β-Hydroxyalanine |
| Stock Status |
In Stock, Production Capacity 35 Tons per Month |
| CAS Number |
312-84-5 |
| Molecular Formula |
C3H7NO3 |
| Molecular Weight |
105.09 g/mol |
| Melting Point |
216.0~222.0℃ |
| Water Solubility |
Soluble in Water (346 mg/ml at 20℃). Insoluble in Alcohol, Ether, Benzene |
| Solubility in Water |
Almost Transparency |
| Storage Temp. |
Cool & Dry Place |
| COA & MSDS |
Available |
| Category |
Amino Acids and Derivatives |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White Crystalline Powder |
Complies |
| Specific Rotation [α]20/D |
-14.5° to -15.5° (C=10, 2N HCl) |
-15.4° |
| Melting Point |
216.0~222.0℃ |
217.0~219.2 |
| Transmittance |
≥98.0% |
98.9% |
| Chloride (as Cl) |
≤0.020% |
<0.020% |
| Sulfate (as SO4) |
≤0.020% |
<0.020% |
| Ammonium (as NH4) |
≤0.020% |
<0.020% |
| Heavy Metals (as Pb) |
≤10ppm |
<10ppm |
| Iron (as Fe) |
≤10ppm |
<10ppm |
| Arsenic (AS2O3) |
≤1ppm |
<1ppm |
| Loss on Drying |
≤0.20% |
0.10% |
| Residue on Ignition |
≤0.10% |
0.09% |
| Chiral Purity |
L-Serine ≤0.50% |
<0.10% |
| Assay |
99.0~101.0% |
99.8% |
| pH |
5.5~6.5 |
5.82 |
| Infrared Spectrum |
Conforms to Structure |
Complies |
| Conclusion |
The product has been tested & complies with the specifications |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
Acidity pH
Take 0.30g of this product, add 30ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 5.5~6.5.
Transmittance of Solution
take 1.0g of this product, add water 20ml to dissolve, according to ultraviolet-visible spectrophotometry (General rule 0401), determine the transmittance at the wavelength of 430mn, not less than 98.0%.
Chloride
Take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 5.0 ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
Sulfate
Take 1.0g of this product and check it according to law (General rule 0802). Compared with the control solution made of 2.0 ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).
Ammonium Salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 2.0 ml of standard ammonium chloride solution, it shall not be deeper (0.02%).
Other Amino Acids
Take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 20mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with water, shake well, as a control solution; Take the appropriate amount of serine reference and methionine reference respectively, and place in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-water-glacial acetic acid (3:1:1) for development, after deployment, air-drying, spraying with ninhydrin in acetone solution (1-50), heating at 80°C until spots appear, and examination immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
Loss on Drying
take this product, dry at 105℃ for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
Residue on Ignition
Not more than 0.1% (General rule 0841).
Iron Salt
Take 1.0g of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy Metals
Take 2.G of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH3.5), and check according to law (the first law of the general rules 0821), containing heavy metals shall not exceed 10 parts per million.
Arsenic Salt
Take this product 2. G, add water 23ml dissolved, add hydrochloric acid 5ml, according to the law inspection (General Principles 0822 first law), should comply with the provisions (0.0001%).
Bacterial Endotoxin
Take this product, check according to law (General 1143), the amount of endotoxin in each lg serine should be less than 12EU. (For injection)
312-84-5 - Content Determination
Take this product about 0.1g, precision weighing, add anhydrous formic acid 1 ml to dissolve, add glacial acetic acid 25ml, according to the potentiometric titration method (General 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 10.51 mg of C3H7N03.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
RTECS VT8200000
TSCA Yes
HS Code 2922491990
D-Serine (H-D-Ser-OH) (CAS: 312-84-5) is the D-form of the amino acid serine, but is not used for the protein synthesis. Amino acids are among the most significant molecules in nature and exist in an l- and a d-form. The chemical and physical properties of l- and d-amino acids are enormously similar except for their optical characteristics[1]. During the emergence of life, only the l-amino acids were selected for the formation of polypeptides and proteins.
Amino acids and derivatives, used in peptide synthesis, used as an organic synthesis intermediate, pharmaceutical intermediate, can be used as a chiral intermediate, biochemical reagent or chemical reagent.
D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.
Production method DL-serine and chloroacetyl chloride are used as raw materials under alkaline conditions, evaporated to dry under reduced pressure, extracted with ethyl acetate, and the product is obtained after treatment with activated carbon and resolution with acylase I.