Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of D-Leucine (H-D-Leu-OH) (CAS: 328-38-1) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase D-Leucine, Please contact: alvin@ruifuchem.com
| Chemical Name |
D-Leucine |
| Synonyms |
H-D-Leu-OH; Dextro-Leucine; (R)-Leucine; D-2-Amino-4-Methylpentanoic Acid; (R)-2-Amino-4-Methylpentanoic Acid |
| Stock Status |
In Stock, Production Capacity 30 Tons per Month |
| CAS Number |
328-38-1 |
| Molecular Formula |
C6H13NO2 |
| Molecular Weight |
131.18 g/mol |
| Melting Point |
>300℃(lit.) |
| Density |
1.035 |
| Water Solubility |
24 g/L (25℃) |
| Solubility in Dilute HCl |
Almost Transparency |
| Storage Temp. |
Cool & Dry Place |
| COA & MSDS |
Available |
| Category |
Amino Acids and Derivatives |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White Crystal or Crystalline Powder |
Complies |
| Specific Rotation [α]20/D |
-14.5° to -16.0° (C=4 in 6N HCl) |
-15.47° |
| Transmittance |
≥98.0% |
99.1% |
| Chloride (Cl) |
≤0.020% |
<0.020% |
| Sulfate (SO4) |
≤0.020% |
<0.020% |
| Ammonium (NH4) |
≤0.020% |
<0.020% |
| Iron (Fe) |
≤10ppm |
<10ppm |
| Heavy Metals (Pb) |
≤10ppm |
<10ppm |
| Arsenic (As2O3) |
≤1ppm |
<1ppm |
| Loss on Drying |
≤0.20% |
0.10% |
| Residue on Ignition |
≤0.10% |
0.07% |
| Other Amino Acids |
≤0.50% |
<0.50% |
| Assay |
98.5~100.5% |
99.5% |
| pH |
5.5~6.5 |
5.7 |
| Infrared Spectrum |
Conforms to Structure |
Complies |
| Conclusion |
The product has been tested & complies with the specifications |
pH
Take 0.50g of this product, add 50ml of water, heat to dissolve, cool, and determine according to law (General 0631),pH value should be 5.5~6.5.
Transmittance of Solution
Take 0.50g of this product, add 50ml of water, heat to dissolve, cool, ultraviolet-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 98.0%.
Chloride
Take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 5.0 ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
Sulfate
Take 1.0g of this product and check it according to law (General rule 0802). Compared with the control solution made of 2.0 ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).
Ammonium Salt
Take this product 0.10g, check according to law (General rule 0808), and compare with the control solution made of standard ammonium chloride solution 2.0 ML, not deeper (0.02%).
Other Amino Acid
Take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 20mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with water, shake, as a control solution; Take the appropriate amount of the leucine reference and the valine reference, and put it in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-water-glacial acetic acid (3:1:1) for development, after deployment, air-drying, spraying with ninhydrin in acetone solution (1-50), heating at 80°C until spots appear, and examination immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
Loss on Drying
Take this product, dry at 105℃ for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
Residue on Ignition
Take 1.0g of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Iron Salt
Take 1.5g of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy Metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Arsenic Salt
Add 5ml water, 1ml sulfuric acid and 10ml sulfurous acid, heat to a volume of about 2ml in a water bath, add 5ml water, add Dropwise ammonia solution until the indicator of phenolphthalein is neutral, add hydrochloric acid 5ml, add water to make 28ml, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (0.0001%).
Bacterial Endotoxin
Take this product, check according to law (General 1143), each lg leucine containing endotoxin should be less than 25EU. (For injection)
328-38-1 - Content Determination
Take this product about 0.1g, precision weighing, add anhydrous formic acid 1 ml dissolved, add glacial acetic acid 25ml, according to the potentiometric titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 13.12 mg of C6H13N02.
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 3
RTECS OH2840000
TSCA Yes
HS Code 2922491990
D-Leucine (H-D-Leu-OH) (CAS: 328-38-1) is the D-Enantiomer of Leucine.
Amino acids and derivatives, used in peptide synthesis, used as an organic synthesis intermediate, pharmaceutical intermediate, can be used as a chiral intermediate, biochemical reagent or chemical reagent.
D-Leucine is an important source of organic chiral, mainly used in chiral drugs, chiral additives, chiral additives and other cross-over. As an optically active organic acid, it plays an irreplaceable role in the asymmetric synthesis of some chiral compounds. At present, it is mainly used for the production of new broad-spectrum antibiotics, D-Leucine, Leucine Protective agent.
Introduction: Leucine is an amino acid that can be found in many proteins and is considered necessary for absorbing a variety of different nutrients; it can be used in biochemical research; Leucine can be used as a nutritional supplement and is very popular with athletes; in addition, leucine can also be used as a food additive to enhance food taste.
Physiological function: Leucine, Isoleucine and Valine are all branched chain amino acids, which help to restore muscles after training, control blood sugar and provide energy to body tissues. Among them, D-Leucine is the most effective branched-chain amino acid, but the human body cannot produce it by itself and can only be obtained through diet. However, there is almost no D-Leucine in ordinary foods. D-Leucine mostly appears in bacterial peptidoglycan. biological activity D-Leucine has antiepileptic activity, which is higher than L-Leucine activity. D-Leucine can effectively terminate epileptic seizures. In vitro, D-Leucine can reduce long-term site, but basal synaptic transmission has no effect. use for biochemical research.
Production method: Acetyl-DL-Leucine is used as raw material, L-Leucine is removed by acylase treatment, then crude product is hydrolyzed in hydrochloric acid, and pure product is obtained after crystallization and refining.