Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-one) (CAS: 381233-78-9) with high quality, intermediate of Perampanel (CAS: 380917-97-5). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Perampanel intermediates, Please contact: alvin@ruifuchem.com
| Perampanel | CAS 380917-97-5 |
| 5-(2-Pyridyl)-1,2-Dihydropyridin-2-one | CAS 381233-78-9 |
| 2-Cyanophenylboronic Acid 1,3-Propanediol Ester | CAS 172732-52-4 |
| Chemical Name | 5-(2-Pyridyl)-1,2-Dihydropyridin-2-one |
| Synonyms | [2,3'-Bipyridin]-6'(1'H)-one; 5-(Pyridin-2-yl)pyridin-2(1H)-one; 5-(Pyridin-2-yl)-2(1H)-Pyridone; 5-(2-Pyridyl)pyridin-2(1H)-one; 5-Pyridin-2-yl-1H-Pyridin-2-one; 5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-one; Perampanel Impurity 1 |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 381233-78-9 |
| Molecular Formula | C10H8N2O |
| Molecular Weight | 172.18 g/mol |
| Melting Point | 71.0~75.0℃ |
| Density | 1.221±0.06 g/cm3 |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | Intermediate of Perampanel (CAS: 380917-97-5) |
| Shelf Life | 24 Months if Stored Properly |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Appearance | White to Almost White Powder | White Powder |
| Purity / Analysis Method | >98.0% (HPLC) | 99.7% |
| Water by Karl Fischer | <1.00% | 0.58% |
| Single Impurity | <1.00% | Complies |
| Total Impurities | <2.00% | 0.30% |
| 1H NMR Spectrum | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application | Intermediate of Perampanel (CAS: 380917-97-5) | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Properties: White to Almost White Powder
Solvent: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Check: Related Substances: Take this product and dilute it with diluent (mobile phase water: methanol (50∶50)) to make a solution containing about 0.5mg per 1ml as the test product solution. According to high performance liquid chromatography (Chinese Pharmacopoeia 2010 Edition II Appendix Ⅴ D), the silica gel (ZORBAX SB-C18 4.6×250mm,5m) was used as the filler. Mobile phase A was water, mobile phase B was methanol, and the detection wavelength was 254nm. The flow rate was 1.0ml/min and the column temperature was room temperature. 5μl of the test solution was accurately measured and injected into the liquid chromatograph to record the chromatogram. According to the area normalization method, the content of this product is not less than 98%. If there are impurity peaks in the chromatogram of the test product solution, the individual impurity peak area shall not exceed 1.0%, and the sum of impurity peak area shall not exceed 2.0%.
Moisture: Take this product, use the moisture tester, according to the Karl Fischer's method (Chinese Pharmacopoeia 2010 edition II Appendix Ⅷ M first method A) determination, moisture content shall not exceed 1.0%.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-one) (CAS: 381233-78-9), an intermediate of Perampanel (CAS: 380917-97-5). Perampanel (licensed in 2012) is a third- generation AED known with the proprietary brand name of Fycompa® (Eisai, Hatfield) in the UK and Banzel® (Eisai, Hatfield) in the USA. Adjunctive treatment of focal seizures with or without secondary generalization and primary generalized tonic- clonic seizures. In October 2012, the US FDA approved perampanel for the treatment of partial onset seizures in epileptic patients who are at least 12 years old. Perampanel is the first AMPA receptor antagonist to receive FDA approval as an AED. AMPA glutamate receptors are found primarily on postsynaptic neurons in the brain. As a selective, noncompetitive antagonist of AMPA, parampanel prevents ion channel opening and reduces propagation of action potential.