Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one (CAS: 27387-31-1) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Please contact: alvin@ruifuchem.com
Related Intermediates of Ondansetron Hydrochloride Dihydrate
| Chemical Name |
1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one |
| Synonyms |
1,2,3,4-Tetrahydro-9-Methylcarbazol-4-one; 1,2,3,4-Tetrahydro-9-Methyl-4-Oxocarbazole |
| Stock Status |
In Stock |
| Impurity |
Ondansetron USP Related Compound C; Ondansetron EP Impurity C; Ondansetron Hydrochloride Dihydrate Impurity C |
| CAS Number |
27387-31-1 |
| Molecular Formula |
C13H13NO |
| Molecular Weight |
199.25 g/mol |
| Melting Point |
199.0 to 203.0℃ |
| Density |
1.21±0.10 g/cm3 |
| COA & MSDS |
Available |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
White to Off-White Crystalline Powder |
Complies |
| Melting Point |
199.0 to 203.0℃ |
200.0 to 202.0℃ |
| Single Impurity |
<0.50% |
Complies |
| Total Impurities |
<1.00% |
Complies |
| Purity / Analysis Method |
>99.0% (HPLC) |
99.65% |
| 1 H NMR Spectrum |
Conforms to Structure |
Complies |
| Conclusion |
The product has been tested & complies with the specifications |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in a tightly closed container. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R25 - Toxic if swallowed
Safety Description
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs UN 2811 6.1 / PGIII
1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one (CAS: 27387-31-1) is used as an intermediate of Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9). The United Kingdom Glaxo company development, 1990 in France, the United Kingdom market. The product is a highly selective serotonin (5-HT3) receptor antagonist, can inhibit Nausea caused by chemotherapy and radiotherapy Vomit, with high strength and high selectivity, can control the small intestine and CTZ receptors caused by the stimulation of Vomit. It is suitable for the treatment of Nausea Vomit caused by chemotherapy and radiotherapy, and can also be used for the prevention and treatment of Nausea Vomit caused after surgery.
Ondansetron, granisetron and dolasetron are three antiemetic drugs commonly used in clinic, ondansetron is a potent, selective and reversible 5-hydroxytryptamine (5-HT3) receptor blocker for Alpha 1, Alpha 2, beta 1, Beta 2 adrenergic receptors and histamine H1, h2 receptor has little effect, and has no antagonistic effect on H receptor, central and peripheral dopaminergic receptors, and can inhibit Nausea and Vomit caused by chemotherapy and radiotherapy. Compared with metoclopramide, The antiemetic effect was strong and there was no extrapyramidal reaction. Cisplatin, cyclophosphamide, doxorubicin caused by Vomit can produce rapid and strong anti-nausea effect. Suitable for the treatment of cytotoxic drugs caused by chemotherapy and radiation therapy Nausea Vomit, but also the prevention and treatment of Nausea Vomit caused by surgery. ondansetron acts as a transfer station between activated visceral afferent nerves in the gastrointestinal tract and Vomit of the centers in the spinal cord, causing abdominal and diaphragmatic movements. Chemotherapy drugs and radiation therapy can cause the release of 5-HT in the small intestine, and the Vomit reflex is caused by the stimulation of the vagus nerve through the 5-HT3 receptor. This product blocks the occurrence of this reflex, while blocking Vomit triggered by central action. The mechanism of action was unknown for Nausea Vomit after surgery. Ondansetron combined with dexamethasone can enhance the antiemetic effect.