Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Brimonidine Tartrate (CAS: 70359-46-5) with high quality. Selective α2-adrenergic receptor agonist, a drug used to treat open-angle glaucoma or ocular hypertension. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Brimonidine Tartrate, Please contact: alvin@ruifuchem.com
| Chemical Name | Brimonidine Tartrate |
| Synonyms | Brimonidine L-Tartrate; UK 14304 Tartrate; AGN190342 Tartrate; 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)quinoxalin-6-Amine Tartrate; 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate; 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)quinoxalin-6-Amine (2R,3R)-2,3-Dihydroxysuccinate |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 70359-46-5 |
| Molecular Formula | C11H10BrN5·C4H6O6 |
| Molecular Weight | 442.23 g/mol |
| Melting Point | 207.0~208.0℃(dec.) |
| Sensitive | Air Sensitive, Heat Sensitive |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Shelf Life | 24 Months if Stored Properly |
| Category | API (Active Pharmaceutical Ingredient) |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White or Slightly Yellowish or Slightly Brownish Powder |
Conforms |
| Identification A | Specific Optical Rotation | Conforms |
| Identification B | Infrared Absorption Spectrophotometry | Conforms |
| Solubility | Soluble in water, practically insoluble in anhydrous ethanol and in toluene | Conforms |
| Specific Optical Rotation | +9.0° ~ +10.5° | +9.6° |
| Loss on Drying | ≤0.50% | 0.20% |
| Sulfated Ash | ≤0.20% | 0.07% |
| Heavy Metals | ≤20ppm | <20ppm |
| Related Substances | ||
| Specified Impurities | ||
| N-(imidazolidin2ylidene)quinoxalin-6-amine | ≤0.10% | Conforms |
| 5-bromoqulinoxalin-6-amine | ≤0.10% | Conforms |
| Quinoxalin-6-amine | ≤0.10% | Conforms |
| 1-(5-bromoquinoxalin-6-yl)thiourea | ≤0.10% | Conforms |
| 2-(5-bromoquinoxalin-6-yl)guanidine | ≤0.10% | Conforms |
| 5-bromo-N-(1H-imidazol-2-yl)Quinoxalin-6-amine | ≤0.10% | Conforms |
| 1-(2-aminoethyl)-3-(5-bromoquinoxalin-6-yl)urea | ≤0.10% | Conforms |
| Unspecified Impurities | ≤0.10% | Conforms |
| Total | ≤0.20% | 0.12% |
| Assay | 99.0%~101.0%(on Dried Basis) | 99.8% |
| Conclusion | This product by inspection accords with the BP2015 Standard | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Avoid exposure to direct sunlight, moisture and excessive heat.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Statements H301: Toxic if swallowed.
Precautionary Statements
P501: Dispose of contents/ container to an approved waste disposal plant.
P270: Do not eat, drink or smoke when using this product.
P264: Wash skin thoroughly after handling.
P301 + P310 + P330: IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405: Store locked up.
Related Laws:
Transport Information:
UN Number (DOT-AIR) UN2811
Class (DOT-AIR) 6.1
Packing Group (TCI-A) III
HS Number 2933.29.9000
Brimonidine Tartrate (CAS: 70359-46-5) is a highly selective α2-receptor blocker, successfully developed by the US Company Allergan, which is an eye medication. It can reduce intraocular pressure (IOP). Brimonidine Tartrate ophthalmic solution saling in the market is Brimonidine Tartrate form, which is a good IOP-lowering medication for chronic open-angle glaucoma and ocular hypertension treatment of patients, but also for argon laser IOP levels. Brimonidine Tartrate ophthalmic solution has a dual mechanism of action by reducing aqueous humor production and increasing the pigment layer of liquid scleral outflow therapeutic purposes. After dropping into the eye, the effect is rapid, and it can reach the peak when using up to 2h, and the effective time can maintain 12h. Blood can only detect traces of drugs. This product has first-pass metabolism in the liver, and metabolites excreted in the urine by the kidneys. Systemic absorption and distribution are not affected, and the elderly do not need dose adjustment. Brimonidine Tartrate ophthalmic solution compared with other α-blockers, the fat-soluble is small, while it does not easy to pass through blood-brain barrier and does not produce sedation, hypotension and other similar clonidine central adverse reactions. Brimonidine Tartrate Ophthalmic Solution is highly selective for α2-adrenergic receptors, and α2/α1 ratio of receptor affinity is more than 1000 times. The effect of alpha 2 receptors can lead to lower intraocular pressure. And the role of the alpha 1 receptors can lead to vascular contraction, eyelid retraction or reduction and dilation of the pupil. Long term application of this product will not cause rapid desensitization. In addition, compared with β-blockers, Brimonidine Tartrate eye drops for minor cardiovascular effects, it has no effect on lung function, so it is suitable for disabled patients β-blockers. Furthermore, when used alone β-blocker, it can not achieve therapeutic purposes, and you can simultaneously increase the FDA.