Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Boc-His(Dnp)-OH·IPA (CAS: 25024-53-7) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase Boc-His(Dnp)-OH·IPA, Please contact: alvin@ruifuchem.com
| Chemical Name | Boc-His(Dnp)-OH·IPA |
| Synonyms | Boc-L-His(Dnp)-OH·IPA; Nα-Boc-Nim-2,4-Dinitrophenyl-L-Histidine·Isopropanol; Boc-Nim-2,4-Dinitrophenyl-L-Histidine; N-Boc-1-(2,4-Dinitrophenyl)-L-Histidine; N-(tert-Butoxycarbonyl)-1-(2,4-Dinitrophenyl)-L-Histidine |
| Stock Status | In Stock |
| CAS Number | 25024-53-7 |
| Molecular Formula | C17H19N5O8·C3H8O |
| Molecular Weight | 481.50 g/mol |
| Melting Point | 98.0~100.0℃ |
| Density | 1.49 |
| Sensitive | Light Sensitive |
| Water Solubility | Slightly Soluble in Water |
| Storage Temp. | Cool & Dry Place (≤8℃) |
| COA & MSDS | Available |
| Category | Boc-Amino Acids |
| Brand | Ruifu Chemical |
| Items | Inspection Standards | Results |
| Appearance | Light Yellow Powder | Complies |
| Melting Point | 98.0~100.0℃ | 98.0~100.0℃ |
| Specific Rotation [α]20/D | +63.0 ± 3.0° (C=1 in EtOAc) |
+63.8° |
| Purity / Analysis Method | >98.5% (HPLC) | 99.37% |
| 300 MHz NMR Spectrum 1H | Conforms to Structure | Complies |
| TLC Analysis | One Spot | Complies |
| IR Spectrum | In Accordance With the Standard | Complies |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
| Main Uses | Boc-Amino Acids; Peptide Synthesis; Pharmaceutical Intermediates | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Light Sensitive, store in dark. Store in sealed containers at cool, dry (≤8℃) warehouse away from incompatible substances. Protect from light and moisture.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Safety Description
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
WGK Germany 3
FLUKA BRAND F CODES 8
TSCA Yes
Boc-His(Dnp)-OH·IPA (CAS: 25024-53-7), the Dnp group is stable to HF and TFMSA. Amino acids and derivatives, peptide synthesis, pharmaceutical intermediates, biochemical reagents. As a typical derivative of L-Histidine, Boc-His(Dnp)-OH·IPA has received more and more attention in the field of pharmaceutical and chemical industry.
Preparation Using 2,4-Dinitrophenyl-L-Histidine as the starting material, the target compound N-(tert-Butoxycarbonyl)-1-(2, 4-Dinitrophenyl)-L-Histidine was prepared by amino protection reaction with ditert-butyl dicarbonate. Fig. 1 experimental operation of synthesis reaction formula of N-(tert-Butoxycarbonyl)-1-(2, 4-Dinitrophenyl)-L-Histidine: 2,4-Dinitrophenyl-L-Histidine is dissolved in 100mL of sodium hydroxide aqueous solution, 200mL of tetrahydrofuran and 250g of ditert-butyl dicarbonate are sequentially added, the pH value is controlled to 8-9, and after 12h of reaction, ethyl acetate is extracted twice, 500mL each time; HCI is used to acidify the aqueous phase to a pH value of 1-2, and ethyl acetate is used to extract the product 3 times, 500mL each time. The ester layers are combined and washed twice with saturated brine, 200 ml. Dry with anhydrous sodium sulfate for 12h, filter, concentrate and crystallize, and dry at 40-50℃ to obtain N-(tert-Butoxycarbonyl)-1-(2, 4-Dinitrophenyl)-L-Histidine.