Ruifu Chemical is the leading manufacturer of Benzyl Chloroformate (Cbz Chloride; Cbz-Cl) (CAS: 501-53-1) with high quality, production capacity 500 tons per year. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Please contact: alvin@ruifuchem.com
| Chemical Name | Benzyl Chloroformate |
| Synonyms | Chloroformic Acid Benzyl Ester; Carbobenzoxy Chloride; Cbz Chloride; Cbz-Cl; Z-Cl; Z-Chloride; (Benzyloxy)carbonyl Chloride; Benzyl Chloridocarbonate; Benzyl Chlorocarbonate; Benzyloxycarbonyl Chloride |
| Stock Status | In Stock, Production Capacity 500 Tons per Year |
| CAS Number | 501-53-1 |
| Molecular Formula | C8H7ClO2 |
| Molecular Weight | 170.59 g/mol |
| Melting Point | -18.0℃ |
| Boiling Point | 178.0~180.0℃ |
| Flash Point | 92.0℃(197.6°F) |
| Specific Gravity (20/20) | 1.210 g/ml |
| Refractive Index n20/D | 1.52 |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Moisture Sensitive, Heat Sensitive |
| Water Solubility | Decomposes |
| Solubility (Soluble in) | Benzene, Toluene, Acetone, Chloroform, Ether |
| Stability | Stable. Incompatible with Water, Oxidizing Agents. Combustible. |
| Odor | Irritating; Sharp, Penetrating. |
| COA & MSDS | Available |
| Origin of Product | China |
| Product Categories | Amino Acids and Peptide Synthesis Reagents; Pesticide Intermediates |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Colorless to Light Yellow Clear Liquid | Complies |
| Benzyl Chloroformate Purity | >97.0% (GC) | 99.7% |
| Density (20℃) | 1.210~1.215 | 1.211 |
| Refractive Index n20/D | 1.516~1.520 | 1.517 |
| Infrared Spectrum | Conforms to Structure | Conforms |
| Stabilizer | 0.1% Na2CO3 | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Fluorinated Bottle, 25kg/Drum, 200kg/Drum, or according to customer's requirement.
Storage: Moisture sensitive. Keep the container tightly closed. Store in a cool, dry, (2~8℃) well-ventilated warehouse away from incompatible substances. Avoid direct sunshine; avoid fire, heat sources; avoid moisture. According to the provisions of the storage and transportation of toxic chemicals.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
Storage in recommended temperatures and conditions will ensure product quality for minimum 12 months, may require retesting after 6 months to determine assay.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes R45 - May cause cancer
R20 - Harmful by inhalation
R34 - Causes burns
R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed.
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R67 - Vapors may cause drowsiness and dizziness
R65 - Harmful: May cause lung damage if swallowed
R63 - Possible risk of harm to the unborn child
R48/20 -
R11 - Highly Flammable
R43 - May cause sensitization by skin contact
R37 - Irritating to the respiratory system
R23 - Toxic by inhalation
Safety Description S53 - Avoid exposure - obtain special instructions before use.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60 - This material and its container must be disposed of as hazardous waste.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S46 - If swallowed, seek medical advice immediately and show this container or label.
S36/37 - Wear suitable protective clothing and gloves.
UN IDs UN 2924 3/PG 2
WGK Germany 3
RTECS LQ5860000
FLUKA BRAND F CODES 19
TSCA Yes
HS Code 2915900090
Hazard Class 8
Packing Group I
Benzyl Chloroformate (Cbz Chloride; Cbz-Cl) (CAS: 501-53-1) is an organic compound that belongs to the family of chloroformates.
Benzyl Chloroformate was first prepared by Leonidas Zervas in the early 1930s who used it for the introduction of the benzyloxycarbonyl protecting group, which became the basis of the Bergmann-Zervas carboxybenzyl method of peptide synthesis he developed with Max Bergmann. This was the first successful method of controlled peptide chemical synthesis and for twenty years it was the dominant procedure used worldwide until the 1950s. To this day, benzyl chloroformate is often used for amine group protection.
Benzyl chloroformate is widely used as a reagent in organic synthesis, especially in the preparation of carboxylic acid derivatives and peptides. It is also used for the protection of amino groups in organic compounds.
Benzyl Chloroformate is used as a reagent in peptide synthesis to protect the amine functionality as the benzyloxycarbonyl (Cbz or Z) derivative. Cbz-protected anilines were prepared directly from aromatic carboxylic acids, sodium azide and Cbz-Cl. Protecting reagent in peptide synthesis.
Benzyl Chloroformate is used as an amino protectant in the synthesis of antibiotics and also as an intermediate in pesticides. Benzyl Chloroformate is widely used as a reactive chemical intermediate in pesticides, pharmaceutical, agricultural and organic chemicals. It is useful for the introduction of carboxybenzyl (cbz) protecting group for amines such as aniline in organic synthesis.
Decomposes in moist air. Decomposes slowly in water to give corrosive hydrochloric acid and organic acids.