Ruifu Chemical is the leading supplier of Aripiprazole (CAS: 129722-12-9) with high quality, API, antipsychotic.
Purchase Aripiprazole or its intermediates, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name |
Aripiprazole |
| Synonyms |
7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]butoxy]-3,4-Dihydro-2(1H)-Quinolinone |
| CAS Number |
129722-12-9 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C23H27Cl2N3O2 |
| Molecular Weight |
448.39 |
| Melting Point |
136.0~140.0℃ |
| Density |
1.263±0.06 g/cm3 |
| Solubility |
Insoluble Soluble in Water; Insoluble in Methanol |
| COA & MSDS |
Available |
| Origin of Product |
Shanghai, China |
| Product Categories |
API (Active Pharmaceutical Ingredient) |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White or Almost White Crystalline Powder |
| Identification |
By IR; By HPLC |
| Solubility |
Soluble in Acetic Acid, Slightly Soluble in Ethanol |
| Melting Point |
136.0~140.0℃ |
| Loss on Drying |
<0.50% |
| Residue on Ignition |
<0.10% |
| Heavy Metals |
≤20ppm |
| Residual Solvents |
|
| Ethanol |
≤1000ppm |
| DMF |
≤200ppm |
| Related Substances |
|
| Any Single Impurity |
<0.20% |
| Total Impurities |
<1.00% |
| Purity / Analysis Method |
>99.0% (HPLC) |
| Assay |
98.0%~102.0% (on the Anhydrous Basis) |
| Micro Limits |
|
| Total Aerobic Microbial Count |
≤1000 cfu/g |
| Yeast and Mold Combined |
≤100 cfu/g |
| E·Coli |
Absence |
| Pathogenic Organizing |
Absence |
| Test Standard |
Enterprise Standard |
Package: Bottle, 5kg/aluminum tin, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
Risk Codes
R11 - Highly Flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36 - Irritating to the eyes
Safety Description
S16 - Keep away from sources of ignition.
S36/37 - Wear suitable protective clothing and gloves.
UN IDs UN 1993C 3 / PGIII
WGK Germany 3
RTECS VC8275950
HS Code 2934 9990.91
Aripiprazole (CAS: 129722-12-9) is a new kind of highly lipid soluble quinoline derivatives, its pharmacological effects characteristic is that it is not only the postsynaptic dopamine D2 receptor antagonist, but also the presynaptic dopamine D2 receptor agonist,it can also excite D1, D3, D4 receptors. Aripiprazole is a second generation atypical antipsychotic and anti-depressant with partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Ki values are 0.34 nM, 0.8 nM, 1.7 nM, and 3.4 nM, respectively, for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors. Aripiprazole is used for the treatment of schizophrenia and related psychotic disorders. Bristol-Myers Squibb and Otsuka Pharmaceutical Company announced that the European Union has approved Abilify (Aripiprazole) in the treatment of schizophrenia listing application. Schizophrenia affects 1% of the global population, and more in young adults. Schizophrenia affects thinking, emotional control and decision-making ability of the patient. Schizophrenia-positive patients will have symptoms such as hallucinations and delusions, patients with negative symptoms are social withdrawal, lack of emotional changes. In 2002 the FDA approved Abilify for the treatment of schizophrenia, which has five dosage strengths: 5 mg, 10 mg, 15 mg, 20 mg and 30 mg, since its approval.