Ruifu Chemical Supply Ivabradine Hydrochloride Intermediates With High Purity
Ivabradine Hydrochloride CAS 148849-67-6
4,5-Dimethoxy-1-Cyanobenzocyclobutane CAS 35202-54-1
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride CAS 866783-13-3
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one CAS 73942-87-7
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one CAS 148870-57-9
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-one CAS 85175-59-3
| Chemical Name | 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one |
| Synonyms | Ivabradine Hydrochloride Intermediate; 7,8-Dimethoxy-1H-benzo[d]azepin-2(3H)-one; 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one |
| CAS Number | 73942-87-7 |
| CAT Number | RF-PI1810 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C12H13NO3 |
| Molecular Weight | 219.24 |
| Density | 1.167 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Off-White to White Powder |
| Identification | HPLC/UV Complies |
| Purity / Analysis Method | >99.0% (HPLC) |
| Melting Point | 244.0~248.0℃ |
| Loss on Drying | <0.50% (Dry it at 60℃ in vacuum till a constant weight) |
| Residue on Ignition | <0.10% |
| Related Substances | |
| Individual Impurity | <0.50% |
| Total Impurities | <1.00% |
| Heavy Metals | <10ppm |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Ivabradine Hydrochloride (CAS 148849-67-6) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one (CAS: 73942-87-7) is an intermediate of Ivabradine Hydrochloride (CAS: 148849-67-6). Ivabradine Hydrochloride, also known as S-16257, is the hydrochloride salt preparation of Ivabradine, a bradycardic agent. Studies have shown that Ivabradine inhibits T cell migration and causes a decrease of chemokine-induced PI-3 kinase activity. Exposure of rabbit sinoatrial node cells to Ivabradine has been reported to cause a blockade of the hyperpolarization-activated If current without resulting in a shift of the voltage range of the activation curve.