Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Methyl 2-(2,3-Dichlorobenzylidine)acetoacetate (CAS: 74073-22-6) with high quality, intermediate of Felodipine (CAS: 72509-76-3; 86189-69-7). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Felodipine intermediates, Please contact: alvin@ruifuchem.com
| Felodipine | CAS: 72509-76-3; 86189-69-7 |
| Methyl 2-(2,3-Dichlorobenzylidine)acetoacetate | CAS: 74073-22-6 |
| 2,3-Dichlorobenzaldehyde | CAS: 6334-18-5 |
| Methyl Acetoacetate (MAA) | CAS: 105-45-3 |
| Methyl 3-Aminocrotonate | CAS: 14205-39-1 |
| Chemical Name | Methyl 2-(2,3-Dichlorobenzylidine)acetoacetate |
| Synonyms | Methyl 2-(2,3-Dichlorobenzylidene)-3-Oxobutanoate; 2-[(2,3-Dichlorophenyl)methylene]-3-Oxobutanoic Acid Methyl Ester; Methyl (2E)-2-[(2,3-Dichlorophenyl)methylidene]-3-Oxobutanoate |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 74073-22-6 |
| Molecular Formula | C12H10Cl2O3 |
| Molecular Weight | 273.11 g/mol |
| Melting Point | 81.0~83.0℃ |
| Density | 1.337 |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Product Categories |
Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White or Light Yellow Crystalline Powder | Light Yellow Crystalline Powder |
| Melting Point | 81.0~83.0℃ | 81.0~81.5℃ |
| Max. Single Impurity | <1.00% | 0.29% |
| Total Impurities | <1.00% | 0.35% |
| Purity / Analysis Method | >99.0% (HPLC) | 99.65% |
| Infrared Spectrum | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application | Intermediate of Felodipine (CAS: 72509-76-3; 86189-69-7) | |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Methyl 2-(2,3-Dichlorobenzylidine)acetoacetate (CAS: 74073-22-6), intermediate of Felodipine (CAS: 72509-76-3; 86189-69-7). Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. Felodipine is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers Felodipine is a 1,4-dihydropyridine small molecule antagonist and calcium channel protein inhibitor. Antagonism of the vascular L-type (long-lasting) calcium channel decreases intracellular calcium concentration, softening the tone of vascular tissue and decreasing the peripheral resistance upon the blood stream, effectively decreasing systemic arterial blood pressure without affecting myocardial contractility. Felodipine is described to inhibit cytokine-induced NO and superoxide production as well as cytokine-induced NO synthase (NOS) mRNA induction, and is suggested to act as a scavenger of superoxide and not an inhibitor of inducible NOS induction. This indicates that Felodipine further protects the vasculature against endogenous free radical generation during inflammatory responses.