Manufacturer Supply Related Intermediates:
Sodium Methanesulfinate CAS 20277-69-4
2-Aminoethyl Methyl Sulfone Hydrochloride CAS 104458-24-4
6-Iodo-4-Hydroxyquinazoline CAS 16064-08-7
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde CAS 231278-84-5
CAS 231277-92-2
CAS 388082-77-7
| Chemical Name |
6-Iodo-4-Hydroxyquinazoline |
| Synonyms |
6-Iodoquinazolin-4-one; 6-Iodo-4-Quinazolinone; 6-Iodoquinazolin-4(3H)-one; 6-Iodo-4(1H)-Quinazolinone; 6-Iodo-4-Quinazolinol |
| CAS Number |
16064-08-7 |
| CAT Number |
RF-PI1627 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C8H5IN2O |
| Molecular Weight |
272.04 |
| Melting Point |
271℃ (lit.) |
| Density |
2.11±0.10 g/cm3 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
Pale Yellow to Brown Crystal Powder |
| Identification |
H-NMR, MS |
| Loss on Drying |
<1.00% |
| Residue on Ignition |
≤0.20% |
| Purity / Analysis Method |
>98.5% (HPLC) |
| 1 H NMR Spectrum |
Consistent With Structure |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of API (CAS: 388082-78-8)
|
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
6-Iodo-4-Hydroxyquinazoline (CAS: 16064-08-7) is an intermediate in the synthesis of API (CAS: 388082-78-8). (CAS: 388082-78-8) is available in 250-mg tablets for oral administrationand is used in combination with Cabecitabine in thetreatment of breast cancer for those patients that over expressthe type 2 EGF-R and who have previously receivedtaxane, anthracycline, and trastuzumab therapy. The type 2EGF-R is one subtype of this receptor and is also known asHER2 or ErbB-2. The agent is a receptor TK inhibitor targetingthe ErbB-1 and ErbB-2 subtypes.