Manufacturer with High Purity and Stable Quality
| Name |
5-Hydroxymethylcytosine |
| Synonyms |
5-HmC |
| CAS Number |
1123-95-1 |
| CAT Number |
RF-PI182 |
| Stock Status |
In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula |
C5H7N3O2 |
| Molecular Weight |
141.13 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White or Off-White Powder |
| Purity / Analysis Method |
≥98.0% (HPLC) |
| Loss on Drying |
≤0.50% |
| Test Standard |
Enterprise Standard |
| Usage |
Pharmaceutical Intermediates; Organic Synthesis |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
5-Hydroxymethylcytosine (5hmC) (CAS: 1123-95-1) is a DNA pyrimidine nitrogen base derived from cytosine. It is potentially important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by TET enzymes. Its molecular formula is C5H7N3O2. It may regulate gene expression or prompt DNA demethylation. 5-Hydroxymethylcytosine (CAS: 1123-95-1) may be especially important in the central nervous system, as it is found in very high levels there. 5-Hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. 5-Hydroxymethylcytosine (CAS: 1123-95-1) is an intermediate metabolite in active DNA demethylation.