Ruifu Chemical is the leading manufacturer of 3-Nitrophthalic Anhydride (CAS: 641-70-3) with high quality, intermediate of Pomalidomide (CAS: 19171-19-8). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 3-Nitrophthalic Anhydride, Please contact: alvin@ruifuchem.com
| Chemical Name |
3-Nitrophthalic Anhydride |
| Synonyms |
3-Nitrophthalic Acid Anhydride; 4-Nitro-2-Benzofuran-1,3-Dione; 4-Nitroisobenzofuran-1,3-Dione; 4-Nitro-1,3-isobenzofurandione; Pomalidomide Impurity A |
| Stock Status |
In Stock, Commercial Production |
| CAS Number |
641-70-3 |
| Molecular Formula |
C8H3NO5 |
| Molecular Weight |
193.11 g/mol |
| Melting Point |
161.0 to 165.0℃ |
| Sensitive |
Moisture Sensitive |
| Water Solubility |
May Decompose in Water |
| COA & MSDS |
Available |
| Origin |
Shanghai, China |
| Brand |
Ruifu Chemical |
| Items |
Inspection Standards |
Results |
| Appearance |
Light Yellow to Yellow Needle Crystal or Crystalline Powder |
Complies |
| Melting Point |
161.0~165.0℃ |
163.0~165.0℃ |
| Loss on Drying |
<0.50% |
0.10% |
| Purity / Analysis Method |
>98.0% (HPLC) |
98.85% |
| Infrared Spectrum |
Consistent with Structure |
Complies |
| 1H NMR Spectrum |
Consistent with Structure |
Complies |
| Conclusion |
The product has been tested and complies with the given specifications |
| Application |
Intermediate of Pomalidomide (CAS: 19171-19-8) |
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Air sensitive. Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire; avoid moisture. Keep away from oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany 3
FLUKA BRAND F CODES 10-21
TSCA Yes
HS Code 2917399090
3-Nitrophthalic Anhydride (CAS: 641-70-3) is used as an intermediate of Pomalidomide (CAS: 19171-19-8). In February 2013, the US FDA approved Pomalidomide for the treatment of multiple myeloma (MM) in patients with disease progression after receiving other cancer therapeutics. Pomalidomide is a 4-amino analog of thalidomide with enhanced potency and an improved toxicity profile. Pomalidomide and thalidomide exert their effects by modulation of immunity, inhibition of angiogenesis, interference with the bone/tumor microenvironment, and inhibition of the cereblon protein. Pomalidomide potently inhibited in vitro proliferation in a variety of human MM cell lines, IC50~10 nM, while thalidomide showed almost no inhibition up to 100 μM. In mouse MM tumor models, 50 mg/kg daily doses of pomalidomide resulted in marked inhibition of tumor growth after 15 days of treatment and complete regression in 3-6 weeks versus thalidomide-treated controls at the same dose. Pomalidomide is prepared by condensation of 3-Nitrophthalic Anhydride with 3-Aminopiperidine-2,6-Dione followed by catalytic hydrogenation of the nitro group.