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Chemical Name: 3-(4-Chlorobutyl)-5-Cyanoindole CAS: 143612-79-7
| Chemical Name |
3-(4-Chlorobutyl)-5-Cyanoindole |
| Synonyms |
3-(4-Chlorobutyl)-1H-Indole-5-Carbonitrile; 3-(4-Chlorobutyl)indole-5-Carbonitrile; Vilazodone Intermediate 8 |
| CAS Number |
143612-79-7 |
| CAT Number |
RF-PI1494 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C13H13ClN2 |
| Molecular Weight |
232.71 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
Off-White to Light Yellow Powder |
| Purity / Analysis Method |
>99.0% (HPLC) |
| Melting Point |
98.0~102.0℃ |
| Moisture (K.F) |
≤0.50% |
| Single Impurity |
≤0.50% |
| Total Impurities |
<1.00% |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Vilazodone Hydrochloride (CAS: 163521-08-2) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
3-(4-Chlorobutyl)-5-Cyanoindole (CAS: 143612-79-7) can be obtained by acylation reaction and reduction reaction of 5-Cyanoindole (CAS: 15861-24-2) and 4-Chlorobutyryl Chloride (CAS: 4635-59-0). 3-(4-Chlorobutyl)-5-Cyanoindole is a key intermediate in the synthesis of Vilazodone Hydrochloride (CAS: 163521-08-2). In January 2011, the U.S. FDA approved Vilazodone Hydrochloridefor the treatment of major depressive disorder (MDD). Vilazodone Hydrochloride is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC50=0.2 nM) with high affinity for 5-HT1A receptors (IC50=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors.